Journal of Medical Laboratory and Diagnosis
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Article Number - 831285047559


Vol.5(4), pp. 35-40 , September 2014
DOI: 10.5897/JMLD2014.0094
ISSN: 2141-2618



Full Length Research Paper

Screening for hemoglobinipathy in Beja tribes and other minor groups living in Port Sudan City



Mohammed Omer Gibreel*,
  • Mohammed Omer Gibreel*,
  • Haematology Department, Port Sudan Ahlia College, Port Sudan, Sudan.
  • Google Scholar
Mubarak El Saeed Elkarsani
  • Mubarak El Saeed Elkarsani
  • Medical Laboratory Sciences, University of Karary, Sudan.
  • Google Scholar
Munsour Mohammed Munsoor
  • Munsour Mohammed Munsoor
  • Hematology Department, Faculty of Medical laboratory Sciences, University of Sudan, Sudan
  • Google Scholar
El Yasaa Ahmed Gubartella
  • El Yasaa Ahmed Gubartella
  • Hematology Department, Faculty of Medical laboratory Sciences, University of Sudan, Sudan
  • Google Scholar







 Received: 13 July 2014  Accepted: 19 August 2014  Published: 30 September 2014

Copyright © 2014 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


Hemoglobinopathies prevalence and distribution among ethnic groups inhabiting the Red Sea State in Sudan were not reported till date. Accordingly, this study has been conducted to address this problem in that area. The study was a cross-sectional descriptive one conducted in Port Sudan city to screen for hemoglobinopathy in anaemic patients referred to three major centers. The study population included 209 patients, 54% males and 46% females with age between 1 and 98 years. Five milliliters of blood were drawn from each subject for CBC (Sysmex KX21), peripheral blood films and hemoglobin electrophoresis using capillary electrophoresis. The results showed that hemoglobinopathy was detected in 59 (28.22%) subjects of whom 26 (44.06%) showed electrophoretic patterns of sickle cell anaemia, 29 (49.15%) Beta thalassaemia trait, 2 (3.38%) hemoglobin D trait, 1 (1.69%) hemoglobin E trait and 1 (1.69%) showed Beta thalassaemia major. The study concluded that occurrence of these frequencies in this population indicated that the target group have hemoglobinopathy and recommended that patients with hemoglobin below lower limits of normal, MCV and MCH lower than 78fl and 27 pg, respectively should be screened for hemoglobinopathy, besides the establishment of a center for diagnosis and control of hemoglobinopathy in that area.

 

Key words: Hemoglobinopathy, Beja tribe, red sea variants, thalassaemia.

Alizadeh S, Bavarsad MS, Dorgalaleh A, Khatib ZK, Dargahi H, Nassiri N, Hamid F, Rahim F, Jaseb K, Saki N (2014). Frequency of beta-thalassemia or beta-hemoglobinopathy carriers simultaneously affected with alpha-thalassemia in Iran. Clin. Lab. 60(6):941-9.
Pubmed
 
Barbara JB (2006). Haemoglobinopathy Diagnosis. Second edition, Oxford UK, Blackwell publishing pp. 70,142.
 
Bashir N, Barkawi M, Sharif L, Momani A, Gharaibeh N (1992) Prevalence of hemoglobinopathies in north Jordan. Trop. Geog. Med. 44(1-2):122-125.
Pubmed
 
Canatan D (2014). Thalassemias and Hemoglobinopathies in Turkey. Hemoglobin 17:1-3.
Crossref
 
Elderdery AY, Mills J, Mohamed BA, Cooper AJ, Mohammed AO, Eltieb N, Old J (2012). Molecular analysis of the β-globin gene cluster haplotypes in a Sudanese population with sickle cell anaemia. Int. J. Lab. Hematol. 34(3):262-266.
Crossref
 

Elderdery AY, Mohamed BA, Cooper AJ, Knight G, Mills J (2011). Tribal distribution of Haemoglobinopathies in a Sudanese patient popula-tion. J. Med. Lab. Diag. 2(4):31-37.

View

 
Firkin F, Chesterman C, Penington D, Rush B (1989) de Gruchy's Clinical Haematology in Medical practice. Fifth edition. United Kingdom, Blackwell Science. pp. 137-170.
 
Galanello R, Offit R (2010). Beta thalassaemia. Orphanet. J. Rare Dis. 5:11.
Crossref
 
Greer JP, Foerster J, Lukens JN (2003). Wintrobe's Clinical Haematology. 11th edition. London: Lippinkott Williams and Willkins publishers. p. 1019.
 
Hoffbrand AV, Catovsky D, Edward GD (2005). Postgraduate haematology. Fifth edition, Volume 1. United Kingdom, Blackwell publishing. pp. 85-103.
Crossref
 
Kaddah N, Rizk S, Kaddah AM, Salama K, Lotfy H (2009) Study of possible genetic factors determining the clinical picture of thalassemia intermedia. J. Med. Sci. 9(3)151-155.
Crossref
 
Kolita TP (2010). Guidelines for the diagnosis of the haemoglobino-pathies in Nigeria. Ann. Ibadan Postgrad. Med. 8(1):25.
 
Modell B, Khan M, Darlison M (2000). Survival in beta-thalassaemia major in the UK: data from the UK Thalassaemia Register. Lancet 355(9220):2051-2052.
Crossref
 
Mohammed AO, Attalla B, Bashir FM, Ahmed FE, El Hassan AM, Ibnauf G, Jiang W, Cavalli-Sforza LL, Karrar ZA, Ibrahim ME (2006). Relationship of the sickle cell gene to the ethnic and geographic groups populating the Sudan. Commun. Genet. 9(2):113-20.
Crossref
 
Munsoor MM, Afaf A (2011). SCT Among relatives of Sickle cell patients in Western Sudan. Can. J. Med. 2(2):20-26.
 
Nagar R, Sinha S, Raman R (2014). Haemoglobinopathies in eastern Indian states: a demographic evaluation. J. Commun. Genet. 1-8.
 
Weatherall DJ (2004). The role of molecular genetics in an evolving global health problem. Am. J. Hum. Genet. 74(3):385-392.
Crossref

 


APA Gibreel*, M. O., El Saeed Elkarsani, M., Munsoor, M. M., & El Yasaa, A. G. (2014). Screening for hemoglobinipathy in Beja tribes and other minor groups living in Port Sudan City. Journal of Medical Laboratory and Diagnosis, 5(4), 35-40.
Chicago Mohammed Omer Gibreel, Mubarak El Saeed Elkarsani, Munsour Mohammed Munsoor and El Yasaa Ahmed Gubartella. "Screening for hemoglobinipathy in Beja tribes and other minor groups living in Port Sudan City." Journal of Medical Laboratory and Diagnosis 5, no. 4 (2014): 35-40.
MLA Mohammed Omer Gibreel, et al. "Screening for hemoglobinipathy in Beja tribes and other minor groups living in Port Sudan City." Journal of Medical Laboratory and Diagnosis 5.4 (2014): 35-40.
   
DOI 10.5897/JMLD2014.0094
URL http://academicjournals.org/journal/JMLD/article-abstract/831285047559

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