Journal of Medical Laboratory and Diagnosis
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Article Number - FAFCABC60558


Vol.7(5), pp. 28-31 , September 2016
DOI: 10.5897/JMLD2016.0132
ISSN: 2141-2618



Short Communication

Blood group serology analysis of one rare case of β-thalassemia major with cold autoantibodies and alloantibodies



Zhi-xin Song
  • Zhi-xin Song
  • Department of Clinical Laboratory, the 3rd Hospital of Sun Yat-Sen University, Guangzhou 510630, Guangdong, China.
  • Google Scholar
Yong Zou
  • Yong Zou
  • Department of Blood Transfusion, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong, China.
  • Google Scholar







 Received: 30 May 2016  Accepted: 25 August 2016  Published: 30 September 2016

Copyright © 2016 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


β thalassemia major is one of major public health problem in south China requiring lifelong blood transfusions for the children to stay alive. However, long-term transfusion increases the risk of the patients to produce the autoantibodies and alloantibodies due to repeated exposure to foreign antigens. In this study, we reported one rare case of β-thalassemia major with cold autoantibodies and alloantibodies. Blood group serology experiments including the absorption-elution test, irregular antibody screening, blood group identification and cross matching were used to determine the blood group serology characteristics of the patient. Results showed that high titer cold autoantibodies and alloantibodies (anti-E and anti-N) were present in serum of the ten-years-old child with β-thalassemia major. Collectively, when difficulties in blood group identification and cross matching were found in patients with β thalassemia major, a prompt and careful blood group serology analysis will help to avoid the transfusion accident due to the undetected antibodies.

 

Key words: Thalassemia, autoantibody, alloantibody, blood type.

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APA Song, Z., & Zou, Y. (2016). Blood group serology analysis of one rare case of β-thalassemia major with cold autoantibodies and alloantibodies. Journal of Medical Laboratory and Diagnosis, 7(5), 28-31.
Chicago Zhi-xin Song and Yong Zou. "Blood group serology analysis of one rare case of β-thalassemia major with cold autoantibodies and alloantibodies." Journal of Medical Laboratory and Diagnosis 7, no. 5 (2016): 28-31.
MLA Zhi-xin Song and Yong Zou. "Blood group serology analysis of one rare case of β-thalassemia major with cold autoantibodies and alloantibodies." Journal of Medical Laboratory and Diagnosis 7.5 (2016): 28-31.
   
DOI 10.5897/JMLD2016.0132
URL http://academicjournals.org/journal/JMLD/article-abstract/FAFCABC60558

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