Journal of Medicinal Plants Research
Subscribe to JMPR
Full Name*
Email Address*

Article Number - 925774355289


Vol.12(1), pp. 1-6 , January 2018
https://doi.org/10.5897/JMPR2017.6542
ISSN: 1996-0875


 Total Views: 0
 Downloaded: 0

Review

Therapeutic and pharmaceutical benefits of native and modified plant pectin



Sutapa Biswas Majee
  • Sutapa Biswas Majee
  • Division of Pharmaceutics, NSHM College of Pharmaceutical Technology, NSHM Knowledge Campus, Kolkata-Group of Institutions, 124 B.L. Saha Road, Kolkata 700053, India.
  • Google Scholar
Dhruti Avlani, Priyanka Ghosh
  • Dhruti Avlani, Priyanka Ghosh
  • Division of Pharmaceutics, NSHM College of Pharmaceutical Technology, NSHM Knowledge Campus, Kolkata-Group of Institutions, 124 B.L. Saha Road, Kolkata 700053, India.
  • Google Scholar
Gopa Roy Biswas
  • Gopa Roy Biswas
  • Division of Pharmaceutics, NSHM College of Pharmaceutical Technology, NSHM Knowledge Campus, Kolkata-Group of Institutions, 124 B.L. Saha Road, Kolkata 700053, India.
  • Google Scholar







 Received: 15 November 2017  Accepted: 13 December 2017  Published: 03 January 2018

Copyright © 2018 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


Plant pectin constitutes an important class of naturally occurring polysaccharides and are widely distributed in various fruits and vegetables consumed on a regular basis. These biomolecules are reported to exhibit a vast array of biological activities including effects on digestive system, chemo-preventive effect in colon cancer, regulation of blood cholesterol level and immune-potentiating effects. However, variation in spectrum of activity and efficacy occurs due to different sources of pectin and also different methods of extraction. Pectin modification by pH treatment, change in temperature or enzymatic modification methods can ensure derivatives with variable but defined degrees of esterification, customized physicochemical properties and improved pharmacological and therapeutic profile, mainly in cancer prevention and management. Pharmaceutical utility of plant pectin is attributed to the unique rheological behavior and gelling properties in aqueous medium and have been successfully employed in development of colon specific sustained release drug delivery systems and edible pectin films with stabilizing effect on entrapped labile molecules. The goal of the review article is to focus on the therapeutic and pharmaceutical benefits of native and modified pectin. Although, several milestones towards understanding the process of pectin modification have been established, most of the data generated till date are obtained from in vitro studies or on commercial varieties of modified pectin. Complete characterization of structure-activity relationships of modified pectin, well-planned in vivo investigations and optimization of pectin-based scaffolds for controlled and targeted drug delivery in oncotherapy are yet to be ascertained for enhancing the marketing potential of these renewable plant-derived biopolymers.

 

Key words: Citrus pectin, edible films, apoptosis, colon cancer, modified pectin.

Beneke CE, Viljoen AM, Hamman JH (2009). Polymeric plant-derived excipients in drug delivery. Molecules 14:2602-2620.
Crossref

 

Chen C, Sheu M, Chen T, Wang Y, Hou W, Liu D, Chung T, Liang Y (2006). Suppression of endotoxin-induced proinflammatory response by citrus pectin through blocking LPS signalling pathways. Biochem. Pharmacol. 72:1001-1009.
Crossref

 
 

Espitia PJ, Du W, Bustillos R, Soares N, McHugh T (2014). Edible films from pectin: Physical-mechanical and antimicrobial properties-A review. Food Hydrocolloids 35:287-296.
Crossref

 
 

Ezugwu AL, Eze SO, Chilaka FC, Anyanwu CU (2012). Production and characterization of pectinases obtained from aspergillus fumigatus in submerged fermentation system using pectin extracted from mango peels as carbon source. Plant Prod. Res. J. 16:30-36.

 
 

Gama B, De Farias Silva CE, Oliveira Da Silva LM, Abud AKS (2015). Extraction and characterization of pectin from citric waste. Chem. Eng. Transactions 44:259-264.

 
 

Georgiev Y, Ognyanoy M, Yanakieva I, Kussovski V, Kratchanova M (2012). Isolation, characterisation and modification of citrus pectin. J. Biosci. Biotechnol. 1:223-233.

 
 

Jackson C, Dreaden T, Theobald L, Tran N, Beal T, Eid M, Gao M, Shirley R, Stoffel M, Kumar V, Mohnen D (2007). Pectin induces apoptosis in human prostate cancer cells: correlation of apoptotic function with pectin structure. Glycobiology 17:805-819.
Crossref

 
 

Kaliana SE, Machado M, Hubinger MD, Menegalli FC (2015). Development of active films from pectin and fruit extracts: light protection, antioxidant capacity, and compounds stability. J. Food Sci. 80:C2389-C2396.
Crossref

 
 

Karaki N, Aljawish A, Humeau C, Muniglia L, Jasniewski J (2016). Enzymatic modification of polysaccharides: Mechanisms, properties, and potential applications: A review. Enzyme Microb. Technol. 90:1-18.
Crossref

 
 

Lee JS, Synytsya A, Kim HB, Choi DJ, Lee S, Lee J, Kim WJ, Jang SJ, Park YI (2013). Purification, characterization and immunomodulating activity of a pectic polysaccharide isolated from Korean mulberry fruit Oddi (Morus alba L.). Int. Immunopharmacol. 17:858-866.
Crossref

 
 

Leclere L, Cutsem PV, Michiels C (2013). Anti-cancer activities of pH- or heat-modified pectin. Front. Pharmacol. 4:1-8.
Crossref

 
 

Majee SB, Avlani D, Biswas GR (2016). Non-starch plant polysaccharides: physicochemical modifications and pharmaceutical applications. J. Appl. Pharm. Sci. 6:234-241.
Crossref

 
 

Majee SB, Biswas GR, Mana S (2012). Insight into natural gums as release modulators in drug delivery systems. LAP LAMBERT Academic Publishing GmbH & Co. KG, Germany. (ISBN 978-3-659-16111-7). Available at: 

View

 
 

May CD (1990). Industrial pectin: Sources, production and applications. Carbohydr. Polym. 12(1):79-99.
Crossref

 
 

Odun-Ayo F, Mellem J, Reddy L (2017). The effect of modified citrus pectin-probiotic on faecal lactobacilli in balb/c mice. J. Food Sci. Technol. 37:478-482.
Crossref

 
 

Ogunka-Nnoka CU, Atinlikou MF (2016). Extraction and characterization of pectin from some selected non-citrus agricultural food wastes. J. Chem. Pharm. Res. 8:283-290.

 
 

Otoni CG, de Moura MR, Aouada FA, Camilloto GP, Cruz RS, Lorevice MV, Soares NFF, Mattoso LHC (2014). Antimicrobial and physical-mechanical properties of pectin/papaya puree/cinnamaldehyde nanoemulsion edible composite films. Food Hydrocolloids 41:188-194.
Crossref

 
 

Plaza M, Abrahamsson V, Turner C (2013). Extraction and neoformation of antioxidant compounds by pressurized hot water extraction from apple by products. J. Agric. Food Chem. 61:5500-5510.
Crossref

 
 

Poiana M, Munteanu M, Bordean D, Gligor R, Alexa E (2013). Assessing the effects of different pectin addition on color quality and antioxidant properties of blackberry jam. Chem. Central J. 7:121.

 
 

Sood N, Mathur A (2013). Evaluation of pharmacological activities of pectin extracted from apple and citrus pomace. Int. J. Biol. Sci. 2(4):1203-1217.

 
 

Sriamornsak P (2003). Chemistry of Pectin and Its Pharmaceutical Uses: A Review. Silpakorn Univ. Int. J. 3(1-2):206-228.

 
 

Srivastava P, Malviya R (2011). Sources of pectin, extraction and its application in pharmaceutical industry - An overview. Indian J. Nat. Prod. Res. 2(1):10-18.

 
 

Tyagi V, Sharma P, Malviya R (2015). Pectin and their role in food and pharmaceutical industry: A review. J. Chronother. Drug Deliv. 6:65-77.

 
 

Wang H, Wei G, Liu F, Banerjee G, Joshi M, Bligh A, Shi S, Lian H, Fan H, Gu X, Wang S (2014). Characterization of two homogalacturonan pectin with immunomodulatory activity from green tea. Int. J. Mole. Sci. 15:9963-9978.
Crossref

 
 

Xiong J, Yang Y, Fu G, Tao L (2015). Novel roles of hydrogen peroxide (H2O2) in regulating pectin synthesis and demethylesterification in the cell wall of rice (Oryza sativa) root tips. New Phytol. J. 94:1854-1862.
Crossref

 
 

Xu H, Tai K, Wei T, Yuan F, Gao Y (2016). Physicochemical and in vitro antioxidant properties of pectin extracted from hot pepper (Capsicum annuum L. var. acuminatum (Fingerh.)) residues with hydrochloric and sulphuric acids. J. Sci. Food Agric. 97:4953-4960.
Crossref

 
 

Zhang W, Xu P, Zhang H (2015). Pectin in cancer therapy: A review. Trends Food Sci. Technol. 44:258-271.
Crossref

 

 


APA Majee, S. B., Avlani, D., Ghosh, P., & Biswas, G. R. (2018). Therapeutic and pharmaceutical benefits of native and modified plant pectin. Journal of Medicinal Plants Research, 12(1), 1-6.
Chicago Sutapa Biswas Majee, Dhruti Avlani, Priyanka Ghosh and Gopa Roy Biswas. "Therapeutic and pharmaceutical benefits of native and modified plant pectin." Journal of Medicinal Plants Research 12, no. 1 (2018): 1-6.
MLA Sutapa Biswas Majee, et al. "Therapeutic and pharmaceutical benefits of native and modified plant pectin." Journal of Medicinal Plants Research 12.1 (2018): 1-6.
   
DOI https://doi.org/10.5897/JMPR2017.6542
URL http://academicjournals.org/journal/JMPR/article-abstract/925774355289

Subscription Form