Journal of Medicinal Plants Research
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Article Number - C74648815811


Vol.4(19), pp. 2004-2006 , October 2010
DOI: 10.5897/JMPR10.363
ISSN: 1996-0875



Full Length Research Paper

Studies on medicinal and toxicological properties of Cajanus cajan, Ricinus communis and Thymus vulgaris leaf extracts


O. l. Oyewole1*, A. A. Owoseniand E. O. Faboro3




1Department of Biochemistry, Osun State University, Osogbo, Osun State, Nigeria.

2Department of Biological Sciences, Bowen University Iwo, Osun State, Nigeria.

3Department of Chemistry, Bowen University Iwo, Osun State, Nigeria.


Email: ioluoye@yahoo.com






 Accepted: 06 August 2010  Published: 04 October 2010

Copyright © 2010 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


Methanolic extracts of the leaves of Cajanus cajan (pigeon pea), Ricinus communis (castor bean) and Thymus vulgaris (thyme) were investigated for their medicinal, antimicrobial and toxicological properties. Phytochemical screening of the leaves revealed the presence of tannins, phlobatannins, flavonoids, steroids, terpenoids, saponins and cardiac glycosides which are the most important bioactive constituents of medicinal plants. Antimicrobial testing against eight pathogenic bacteria showed that all the extracts possess antimicrobial properties with Thymus vulgaris being the most effective as it inhibited seven out of the eight bacteria tested. Rats were given daily oral administration of methanolic extracts of the leaves at two different concentrations (100 mg and 200 mg/kg body weight) for a period of 14 days. Analysis of kidney and liver function parameters in the serum and tissues of the rats show no significant difference (P < 0.05) between treated and untreated rats. Measurement of organ: body weight ratio did not show any indication of kidney or liver enlargement. These results showed that the extracts are not toxic and also possess medicinal components which are inhibitory to bacteria.

 

Key words:  Cajanus cajan, Ricinus communis, Thymus vulgaris, antimicrobial, toxicity.


APA (2010). Studies on medicinal and toxicological properties of Cajanus cajan, Ricinus communis and Thymus vulgaris leaf extracts. Journal of Medicinal Plants Research, 4(19), 2004-2006.
Chicago O. l. Oyewole, A. A. Owoseni and E. O. Faboro. "Studies on medicinal and toxicological properties of Cajanus cajan, Ricinus communis and Thymus vulgaris leaf extracts." Journal of Medicinal Plants Research 4, no. 19 (2010): 2004-2006.
MLA O. l. Oyewole, A. A. Owoseni and E. O. Faboro. "Studies on medicinal and toxicological properties of Cajanus cajan, Ricinus communis and Thymus vulgaris leaf extracts." Journal of Medicinal Plants Research 4.19 (2010): 2004-2006.
   
DOI 10.5897/JMPR10.363
URL http://academicjournals.org/journal/JMPR/article-abstract/C74648815811

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