Journal of Neuroscience and Behavioral Health
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Article Number - 33A828D61832


Vol.8(4), pp. 20-26 , November 2016
DOI: 10.5897/JNBH2015.0130
ISSN: 2141-2286



Full Length Research Paper

Vitamin B complex and homocysteine status and Cognitive impairment in the elderly among Indian population



Basheer, M. P.
  • Basheer, M. P.
  • MES Medical College, Kerala, India.
  • Google Scholar
Soopy, K.
  • Soopy, K.
  • Govt. Medical College Calicut, Kerala, India.
  • Google Scholar
Pradeep Kumar, K. M.
  • Pradeep Kumar, K. M.
  • Govt. Medical College Calicut, Kerala, India.
  • Google Scholar
Sreekumaran, E.
  • Sreekumaran, E.
  • Department of Life Sciences, University of Calicut, Kerala, India.
  • Google Scholar
Ramakrishna, T.
  • Ramakrishna, T.
  • Department of Life Sciences, University of Calicut, Kerala, India.
  • Google Scholar







 Received: 21 May 2015  Accepted: 10 November 2016  Published: 30 November 2016

Copyright © 2016 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


Vitamins B complex and homocysteine has been given much attention as preventive factors against cognitive decline and dementia. Hyper homocysteinaemia has been suggested as a cause or mechanism in the development of Alzheimer’s disease and other forms of dementia. The present study is designed to know the role of vitamin B complex and homocysteine and its relation with cognition, using biological samples. A total of 337 subjects with a mean age of 49 years participated in the cross sectional study from different parts of Kerala state in India. Participants were administered a series of neuropsychological test batteries with major emphasis on 7-min screen test. All test procedures were administered by standard protocol after a written consent was obtained from the participating subjects. Analysis of vitamin B complex and homocysteine was done, using serum samples and the data obtained was then statistically analyzed using statistical package for social sciences (SPSS) software version 17. Vitamin B6 and B9 were found to be significantly related to the cognitive score (P < 0.001, p < 0.003, respectively). Independent sample test showed a highly significant change with a p value < 0.048 and < 0.019 of vitamin B12 and homocysteine, respectively. The results of our study give us an insight that Vitamin B complex and homocysteine may be closely associated with cognitive function in elderly population. But further studies on a larger population is required to come out with a definite conclusion.

 

Key words: Cognition, vitamin B6, folic acid, vitamin B12, homocysteine, dementia.

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APA Basheer, M. P., Soopy, K., Pradeep Kumar, K. M., Sreekumaran, E., & Ramakrishna, T. (2016). Vitamin B complex and homocysteine status and Cognitive impairment in the elderly among Indian population. Journal of Neuroscience and Behavioral Health, 8(4), 20-26.
Chicago Basheer, M. P.,, Soopy, K., Pradeep Kumar, K. M., Sreekumaran, E. and Ramakrishna, T.. "Vitamin B complex and homocysteine status and Cognitive impairment in the elderly among Indian population." Journal of Neuroscience and Behavioral Health 8, no. 4 (2016): 20-26.
MLA Basheer, et al. "Vitamin B complex and homocysteine status and Cognitive impairment in the elderly among Indian population." Journal of Neuroscience and Behavioral Health 8.4 (2016): 20-26.
   
DOI 10.5897/JNBH2015.0130
URL http://academicjournals.org/journal/JNBH/article-abstract/33A828D61832

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