Journal of Neuroscience and Behavioral Health
Subscribe to JNBH
Full Name*
Email Address*

Article Number - 8A72D893957


Vol.2(2), pp. 007-011 , March 2010

ISSN: 2141-2286



Full Length Research Paper

NutriSim© protects against hippocampal neuronal damage induced by ischemia-reperfusion in Mongolian gerbils (Meriones unguiculatus): Morphological and biochemical approach


Rolando Romero Dávalos1, P. Fermín Pacheco-Moisés2*, Armida Miranda-Riestra3, Carmen Barajas-Martínez2, Ariana Navarro-Meléndez2, Sergio Rodríguez-Reynoso4, Irma E. Velázquez-Brizuela5, J. A. Cruz-Ramos3 and Genaro Gabriel Ortiz3




1Laboratorios BioSim©; Área de Desarrollo e Investigación Científica. México D. F.

2Departamento de Química, Centro Universitario de Ciencias Exactas e Ingenierías. Universidad de Guadalajara. Guadalajara, Jalisco. México.

3Laboratorio de Estrés Oxidativo, División de Neurociencias. Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social. Guadalajara, Jalisco.México.

4División de Investigación Quirúrgica, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social. Guadalajara, Jalisco. México.

5OPD Instituto Jalisciense de Cancerología, Guadalajara, Jalisco. México.


Email: ferminpacheco@hotmail.com.






 Published: 20 March 2009

Copyright © 2009 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


Mongolian gerbil model has been extensively used for the study of neuroprotective drugs since transient bilateral common carotid artery occlusion induces neuronal cell death to selectively vulnerable regions, including the CA1 sector of the hippocampus. Oxidative stress is strongly involved in this phenomenon. NutriSim© a nutritive supplement has been used empirically in the treatment of several degenerative disorders. Therefore in the present work we studied the ability of NutriSim© to protect against brain damage induced by ischemia-reperfusion in Mongolian gerbils. Brain damage was monitored by histological analysis of CA1 region and quantitative determinations of lipoperoxides, nitric oxide catabolites (nitrates/nitrites) and glutathione peroxidase enzyme (GPx) activity. We found that a single dose of NutriSim© reduces hippocampal neuronal death in the CA1 of the hippocampus and attenuates increases in lipid peroxidation products (malondialdehyde and 4-hydroxyalkenals), nitric oxide catabolites (nitrates/nitrites) and GPx activity. These results suggest that neuroprotective effects of NutriSim© are partly attributed to its antioxidant action.

 

Key words:  NutriSim©, hippocampus, ischemia-reperfusion.


APA (2010). NutriSim© protects against hippocampal neuronal damage induced by ischemia-reperfusion in Mongolian gerbils (Meriones unguiculatus): Morphological and biochemical approach. Journal of Neuroscience and Behavioral Health, 2(2), 007-011.
Chicago Rolando Romero D&avalos, P. Ferm&in Pacheco-Mois&es, Armida Miranda-Riestra, Carmen Barajas-Mart&inez, Ariana Navarro-Mel&endez, Sergio Rodr&iguez-Reynoso, Irma E. Vel&azquez-Brizuela, J. A. Cruz-Ramos and Genaro Gabriel Ortiz. "NutriSim© protects against hippocampal neuronal damage induced by ischemia-reperfusion in Mongolian gerbils (Meriones unguiculatus): Morphological and biochemical approach." Journal of Neuroscience and Behavioral Health 2, no. 2 (2010): 007-011.
MLA Rol, et al. "NutriSim© protects against hippocampal neuronal damage induced by ischemia-reperfusion in Mongolian gerbils (Meriones unguiculatus): Morphological and biochemical approach." Journal of Neuroscience and Behavioral Health 2.2 (2010): 007-011.
   
DOI
URL http://academicjournals.org/journal/JNBH/article-abstract/8A72D893957

Subscription Form