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Article Number - 39671F159720


Vol.7(4), pp. 23-27 , July 2016
https://doi.org/10.5897/JPAP2015.0104
ISSN: 2141-260X


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Full Length Research Paper

Age-related effects of lead poisoning on sex hormones in adult male Wistar rats



A. B. Daku
  • A. B. Daku
  • Department of Human Physiology Faculty of Medicine, Federal University, Dutse, Nigeria.
  • Google Scholar
A. I. Salisu
  • A. I. Salisu
  • Department of Human Physiology Faculty of Basic Medical Sciences, Bayero University, Kano, Nigeria.
  • Google Scholar
A. B. El-ta’alu
  • A. B. El-ta’alu
  • Department of Human Physiology Faculty of Basic Medical Sciences, Bayero University, Kano, Nigeria.
  • Google Scholar







 Received: 09 December 2015  Accepted: 26 February 2016  Published: 31 July 2016

Copyright © 2016 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


The World Health Organization (WHO) estimates that, about a quarter of the diseases facing mankind today occur due to prolonged exposure to environmental pollution, and that most of these environment-related diseases are however, not easily detected and may be acquired during childhood and manifested later in adulthood. The aim of this work was to determine the sub-chronic effects of lead poisoning on and some sex hormones, as well as age-related changes on Wistar Rats. Thirty (30) of 3-, 5-, and 7-months old age-groups male Wistar rats were selected; each age group was divided into experimental (lead fed) and control (distil water fed) groups. The levels of sex hormones (LH, FSH and Testestrone) were measured using ELISA method, while blood lead concentration was determined using the method of Atomic Absorption Spectrophotometer. There was a significant (P<0.05) increase between experimental and control groups in blood lead concentration and insignificant (P˃0.05) increase in LH in both experimental and  control groups. Significant (P<0.05) decrease in body weight, testosterone levels, FSH was observed between experimental and control groups. The effect of lead (Pb) on testosterone levels was more pronounced in older animals. It was concluded that, ingestion of lead acetate has an age related effect on male sex hormones in older rats.

Key words: Sex hormones, lead, male, Wistar rats.

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APA Daku, A. B., Salisu, A. I., & El-ta’alu, A. B. (2016). Age-related effects of lead poisoning on sex hormones in adult male Wistar rats. Journal of Physiology and Pathophysiology, 7(4), 23-27.
Chicago A. B. Daku, A. I. Salisu and A. B. El-ta’alu. "Age-related effects of lead poisoning on sex hormones in adult male Wistar rats." Journal of Physiology and Pathophysiology 7, no. 4 (2016): 23-27.
MLA A. B. Daku, A. I. Salisu and A. B. El-ta’alu. "Age-related effects of lead poisoning on sex hormones in adult male Wistar rats." Journal of Physiology and Pathophysiology 7.4 (2016): 23-27.
   
DOI https://doi.org/10.5897/JPAP2015.0104
URL http://academicjournals.org/journal/JPAP/article-abstract/39671F159720

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