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Article Number - 5D782A462439


Vol.8(1), pp. 1-6 , January 2017
https://doi.org/10.5897/JPAP2016.0107
ISSN: 2141-260X


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Full Length Research Paper

Oxytocin ameliorates the deleterious effect of pain in adult male rats



Nessren M. Abd el-Rady
  • Nessren M. Abd el-Rady
  • Department of Physiology, Faculty of Medicine, Assiut University, Assiut, Egypt.
  • Google Scholar
Omyma G. Ahmed
  • Omyma G. Ahmed
  • Department of Physiology, Faculty of Medicine, Assiut University, Assiut, Egypt.
  • Google Scholar
Ebtihal A. Abd El-Aziz
  • Ebtihal A. Abd El-Aziz
  • Department of Physiology, Faculty of Medicine, Assiut University, Assiut, Egypt.
  • Google Scholar
Ayman M. Osman
  • Ayman M. Osman
  • Department of Anesthesia and Intensive Care, Faculty of Medicine, Assiut University, Assiut, Egypt.
  • Google Scholar
Amel Taha
  • Amel Taha
  • Department of Histology. Faculty of Medicine, Assiut University, Assiut, Egypt.
  • Google Scholar







 Received: 18 August 2016  Accepted: 14 September 2016  Published: 31 January 2017

Copyright © 2017 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


Oxytocin (OXT) is a neuropeptide with a peripheral role in reproduction, though it may have a central effect. The aim of the study is to verify its cental pathophysiological mechanisms on experimental rats. Rats were divided into control, OXT (which divided into intrathecal OXT and IV OXT subgroups), and antagonist group: OXT and l-glutamate Na+ subgroup with measuring of pain threshold, cardiovascular changes, and pain related mediators (OXT, serotonin, and dopamine) and histopathological examination. A significant increase of the pain threshold in rats was observed in intrathecal oxytocin subgroup. The response was absent in IV oxytocin subgroup The analgesic effect of OXT contributes to direct increase of OXT receptors maker in different brain areas and spinal cord and through glutamergic pathway. Besides, OXT induces significant increase in the levels of neurotransmitters related to the pain in serum and brain homogenate of this experimental study. Administration of OXT can counterbalance the pain troubles without major detectable detrimental effects on cardiovascular system.

Key words: Oxytocin (OXT), neuropeptide, cardiovascular system, glutamergic pathway, serotonin and dopamine.

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APA Abd el-Rady, N. M., Ahmed, O. G., Abd El-Aziz, E. A., Osman, A. M., & Taha, A. (2017). Oxytocin ameliorates the deleterious effect of pain in adult male rats. Journal of Physiology and Pathophysiology, 8(1), 1-6.
Chicago Nessren M. Abd el-Rady, Omyma G. Ahmed, Ebtihal A. Abd El-Aziz, Ayman M.Osman and Amel Taha. "Oxytocin ameliorates the deleterious effect of pain in adult male rats." Journal of Physiology and Pathophysiology 8, no. 1 (2017): 1-6.
MLA Nessren M. Abd el-Rady, et al. "Oxytocin ameliorates the deleterious effect of pain in adult male rats." Journal of Physiology and Pathophysiology 8.1 (2017): 1-6.
   
DOI https://doi.org/10.5897/JPAP2016.0107
URL http://academicjournals.org/journal/JPAP/article-abstract/5D782A462439

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