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Article Number - 69D127356897


Vol.7(1), pp. 1-6 , January 2016
https://doi.org/10.5897/JPAP2015.0099
ISSN: 2141-260X


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Full Length Research Paper

Effects of Gmelina arborea, Roxb (Verbenaceae) aqueous extract on arterial pressure of Wistar rats



Roland Lawson
  • Roland Lawson
  • Unité de Physiologie, Faculté des Sciences de la Santé, Université d’Abomey-Calavi, Cotonou, Benin.
  • Google Scholar
Bonaventure Awede
  • Bonaventure Awede
  • Unité de Physiologie, Faculté des Sciences de la Santé, Université d’Abomey-Calavi, Cotonou, Benin.
  • Google Scholar
Razack Osseni
  • Razack Osseni
  • Unité de Physiologie, Faculté des Sciences de la Santé, Université d’Abomey-Calavi, Cotonou, Benin.
  • Google Scholar
Fernand Gbaguidi
  • Fernand Gbaguidi
  • Laboratoire de Pharmacognosie et des Huiles Essentielles, Faculté des Sciences de la Santé - Faculté des Sciences et Techniques, Université d’Abomey-Calavi, Cotonou, Benin.
  • Google Scholar
Joachim Gbenou
  • Joachim Gbenou
  • Laboratoire de Pharmacognosie et des Huiles Essentielles, Faculté des Sciences de la Santé - Faculté des Sciences et Techniques, Université d’Abomey-Calavi, Cotonou, Benin.
  • Google Scholar
Anatole Laleye
  • Anatole Laleye
  • Unité de Biologie Humaine, Faculté des Sciences de la Santé, Université d’Abomey-Calavi, Cotonou, Benin.
  • Google Scholar







 Received: 31 May 2015  Accepted: 10 December 2015  Published: 31 January 2016

Copyright © 2016 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


In this study, the effect of Gmelina arborea aqueous extract, a medicinal plant used in the treatment of hypertension, on rat blood pressure was investigated. After harvest, leaves of G. arborea were dried, reduced in powder and used for aqueous extract preparation. The aqueous extract was administrated at 500 mg/kg/day to Wistar rats, which has been made hypertensive by NG-Nitro-L-arginine methyl ester (L-NAME), treatment at 20 mg/kg/day. Alkaloid compounds, tannins, anthocyanins, leucoanthocyanins, mucilages and saponins were detected in G. arborea leaves. 7 and 14 days administration of L-NAME induced an increase of mean arterial blood pressure from 99±4 mmHg to respectively 155±2 and 179±10 mmHg. G. arborea leaves extract reduced these blood pressures to respectively 126±13 and 147±7 mmHg. These data confirm the antihypertensive effect of G. arborea leaves. Further investigations will analyze the active compounds and the molecular mechanisms underlying this pharmacological effect.

Key words:  Hypertension, L-NAME, medicinal plant, G. arborea.

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APA Lawson, R., Awede, B., Osseni, R., Gbaguidi, F., Gbenou, J. & Laleye, A. (2016). Effects of Gmelina arborea, Roxb (Verbenaceae) aqueous extract on arterial pressure of Wistar rats. Journal of Physiology and Pathophysiology, 7(1), 1-6.
Chicago Roland Lawson, Bonaventure Awede, Razack Osseni, Fernand Gbaguidi, Joachim Gbenou and Anatole Laleye. "Effects of Gmelina arborea, Roxb (Verbenaceae) aqueous extract on arterial pressure of Wistar rats." Journal of Physiology and Pathophysiology 7, no. 1 (2016): 1-6.
MLA Rol, et al. "Effects of Gmelina arborea, Roxb (Verbenaceae) aqueous extract on arterial pressure of Wistar rats." Journal of Physiology and Pathophysiology 7.1 (2016): 1-6.
   
DOI https://doi.org/10.5897/JPAP2015.0099
URL http://academicjournals.org/journal/JPAP/article-abstract/69D127356897

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