Journal of Pharmacognosy and Phytotherapy
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Article Number - 2D7E7B862099

Vol.9(1), pp. 1-5 , January 2017
DOI: 10.5897/JPP2015.0399
ISSN: 2141-2502

Full Length Research Paper

Chemical composition and anticancer activity of Achillea fragrantissima (Forssk.) Sch. Bip. (Asteraceae) essential oil from Egypt

Mouchira Aly Choucry
  • Mouchira Aly Choucry
  • Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.
  • Google Scholar

 Received: 07 May 2016  Accepted: 17 October 2016  Published: 31 January 2017

Copyright © 2017 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0

The aerial parts of Achillea fragrantissima (Forssk.) Sch. Bip., wildly grown in Egypt, yielded 0.8 and 1.5% (v/w) of essential oils prepared by hydrodistillation (HD), or by conventional volatile solvent extraction method (preparation of the “absolute”, SE), respectively.  The volatile components of this essential oil were determined by GC–MS analyses. Twenty eight compounds were identified in the HD sample, among which caryophyllene oxide (23.50%), 1-terpinen-4-Ol (11.15%), viridiflorol and guaienol (9.84%) were the main components. Meanwhile, 21 compounds were detected in the SE sample; 1-terpinen-4-Ol (30.90%), p-cymen-3-Ol (21.22%) were the main components. The anticancer activity of the prepared oils was evaluated against human breast cancer cell line (MCF-7) and colon cancer cell line (HCT116). The oil prepared by hydrodistillation revealed an IC50 0.51 µg/ml for MCF-7 and 0.62 µg /ml for HCT116, while that prepared by volatile solvent extraction had a value of 0.80 µg/ml for MCF-7 and 0.91 µg /ml for HCT116.

Key words: Achillea fragrantissima, cytotoxic and terpinen-4-ol.

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APA Choucry, M. A. (2017). Chemical composition and anticancer activity of Achillea fragrantissima (Forssk.) Sch. Bip. (Asteraceae) essential oil from Egypt. Journal of Pharmacognosy and Phytotherapy, 9(1), 1-5.
Chicago Mouchira Aly Choucry. "Chemical composition and anticancer activity of Achillea fragrantissima (Forssk.) Sch. Bip. (Asteraceae) essential oil from Egypt." Journal of Pharmacognosy and Phytotherapy 9, no. 1 (2017): 1-5.
MLA Mouchira Aly Choucry. "Chemical composition and anticancer activity of Achillea fragrantissima (Forssk.) Sch. Bip. (Asteraceae) essential oil from Egypt." Journal of Pharmacognosy and Phytotherapy 9.1 (2017): 1-5.
DOI 10.5897/JPP2015.0399

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