Journal of Parasitology and Vector Biology
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Article Number - 51AB4DB47021


Vol.6(9), pp. 131-141 , September 2014
DOI: 10.5897/JPVB2014.0158
ISSN: 2141-2510



Full Length Research Paper

Determination of insecticidal effect (LCD50 and LCD90) of organic fatty acids mixture (C8910+silicone) against malaria vectors



James C. Dunford*
  • James C. Dunford*
  • Navy and Marine Corps Public Health Center Detachment, Centers for Disease Control and Prevention, Atlanta, GA, 30341, USA.
  • Google Scholar
Robert A. Wirtz
  • Robert A. Wirtz
  • Centers for Disease Control and Prevention, Atlanta, GA, 30341, USA.
  • Google Scholar
William G. Reifenrath
  • William G. Reifenrath
  • Stratacor, Inc., Richmond, CA, 94804, USA.
  • Google Scholar
Aneika Falconer
  • Aneika Falconer
  • Centers for Disease Control and Prevention, Atlanta, GA, 30341, USA.
  • Google Scholar
Laura N. Leite
  • Laura N. Leite
  • Centers for Disease Control and Prevention, Atlanta, GA, 30341, USA.
  • Google Scholar
and William G. Brogdon
  • and William G. Brogdon
  • Centers for Disease Control and Prevention, Atlanta, GA, 30341, USA.
  • Google Scholar







 Received: 08 June 2014  Accepted: 14 August 2014  Published: 30 September 2014

Copyright © 2014 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


Malaria vectors have acquired widespread resistance to several insecticides; thus, there is a critical need for the development of alternative insecticides for use in vector control programs. The mosquito toxicity of a novel insecticide/repellent consisting of medium-chain carbon fatty acids (C8910) was examined. Determination of LCD50 and LCD90 was made against six colony-reared Anopheles species using probit analysis on mortality data generated by Centers for Disease Control and Prevention bottle bioassays. Eight different concentrations of C8910+silicone oil provided an LCD50 ranging from 55.4 (44.2 to 65.9) in Anopheles minimus to 132.6 (92.8 to 301.3) in Anopheles dirus. Similarly, LCD90 varied from 138.5 (107.9 to 207.9) to 1228.8 (449.8 to 21400), respectively. Further development of C8910 and similar compounds could provide vector control specialists novel, environmentally-safe insecticides for controlling insect disease vectors.

 

Key words: LCD50, LCD90, bottle bioassay, C8910, silicone, malaria, Anopheles.

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APA Dunford, J. C., Wirtz, R. A., Reifenrath, W. G., Falconer, A., Leite, L. N. & Brogdon, W. G. (2014). Determination of insecticidal effect (LCD50 and LCD90) of organic fatty acids mixture (C8910+silicone) against malaria vectors. Journal of Parasitology and Vector Biology, 6(9), 131-141.
Chicago James C. Dunford, Robert A. Wirtz, William G. Reifenrath, Aneika Falconer, Laura N. Leite and William G. Brogdon. "Determination of insecticidal effect (LCD50 and LCD90) of organic fatty acids mixture (C8910+silicone) against malaria vectors." Journal of Parasitology and Vector Biology 6, no. 9 (2014): 131-141.
MLA James C. Dunford, et al. "Determination of insecticidal effect (LCD50 and LCD90) of organic fatty acids mixture (C8910+silicone) against malaria vectors." Journal of Parasitology and Vector Biology 6.9 (2014): 131-141.
   
DOI 10.5897/JPVB2014.0158
URL http://academicjournals.org/journal/JPVB/article-abstract/51AB4DB47021

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