Journal of
Parasitology and Vector Biology

  • Abbreviation: J. Parasitol. Vector Biol.
  • Language: English
  • ISSN: 2141-2510
  • DOI: 10.5897/JPVB
  • Start Year: 2009
  • Published Articles: 153

Full Length Research Paper

Determination of insecticidal effect (LCD50 and LCD90) of organic fatty acids mixture (C8910+silicone) against malaria vectors

James C. Dunford*
  • James C. Dunford*
  • Navy and Marine Corps Public Health Center Detachment, Centers for Disease Control and Prevention, Atlanta, GA, 30341, USA.
  • Google Scholar
Robert A. Wirtz
  • Robert A. Wirtz
  • Centers for Disease Control and Prevention, Atlanta, GA, 30341, USA.
  • Google Scholar
William G. Reifenrath
  • William G. Reifenrath
  • Stratacor, Inc., Richmond, CA, 94804, USA.
  • Google Scholar
Aneika Falconer
  • Aneika Falconer
  • Centers for Disease Control and Prevention, Atlanta, GA, 30341, USA.
  • Google Scholar
Laura N. Leite
  • Laura N. Leite
  • Centers for Disease Control and Prevention, Atlanta, GA, 30341, USA.
  • Google Scholar
and William G. Brogdon
  • and William G. Brogdon
  • Centers for Disease Control and Prevention, Atlanta, GA, 30341, USA.
  • Google Scholar


  •  Received: 08 June 2014
  •  Accepted: 14 August 2014
  •  Published: 30 September 2014

Abstract

Malaria vectors have acquired widespread resistance to several insecticides; thus, there is a critical need for the development of alternative insecticides for use in vector control programs. The mosquito toxicity of a novel insecticide/repellent consisting of medium-chain carbon fatty acids (C8910) was examined. Determination of LCD50 and LCD90 was made against six colony-reared Anopheles species using probit analysis on mortality data generated by Centers for Disease Control and Prevention bottle bioassays. Eight different concentrations of C8910+silicone oil provided an LCD50 ranging from 55.4 (44.2 to 65.9) in Anopheles minimus to 132.6 (92.8 to 301.3) in Anopheles dirus. Similarly, LCD90 varied from 138.5 (107.9 to 207.9) to 1228.8 (449.8 to 21400), respectively. Further development of C8910 and similar compounds could provide vector control specialists novel, environmentally-safe insecticides for controlling insect disease vectors.

 

Key words: LCD50, LCD90, bottle bioassay, C8910, silicone, malaria, Anopheles.