Journal of
Toxicology and Environmental Health Sciences

  • Abbreviation: J. Toxicol. Environ. Health Sci.
  • Language: English
  • ISSN: 2006-9820
  • DOI: 10.5897/JTEHS
  • Start Year: 2009
  • Published Articles: 179

Full Length Research Paper

Lactate and creatine phosphokinase as potential independent predictors of organophosphrus poisoning severity in Zagazig University Hospital Patients, Egypt

Manar H. Arafa
  • Manar H. Arafa
  • Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Zagazig University, Zagazig, Skarkia, Egypt.
  • Google Scholar
Nashwa M. Shalaby
  • Nashwa M. Shalaby
  • Department of Biochemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Skarkia, Egypt.
  • Google Scholar
Hebatallah H. Atteia
  • Hebatallah H. Atteia
  • Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tabuk, Tabuk, Kingdom Saudi Arabia.
  • Google Scholar


  •  Accepted: 06 October 2017
  •  Published: 31 October 2017

Abstract

This study aimed to assess the correlation of serum lactate and creatine phosphokinase (CPK) levels, and their association with severity of organophosphrus poisoning in order to use one of them or both as tools in predicting prognosis. This study was conducted over one year and 68 organophosphate (OP)-poisoned patients were enrolled. Clinical severity of cases was categorized according to Peradeniya organophosphorus poisoning (POP) scale. Levels of serum acetyl choline esterase (AChE), serum CPK and serum lactate were measured on admission (0 h), 6 and 24 h post-ingestion. The results showed a high statistically significant difference between cases and control regarding AChE, CPK and lactate on admission. Also, there was high statistically significant difference regarding AChE, CPK and lactate among different categories of cases on admission, 6 and 24 h post admission. In addition, there was a statistically significant increase among different categories of POP scale regarding the quantity of atropine used in management of cases. Regarding oximes and stay in ICU, there was a statistically significant increase in severe poisoned patients when compared with moderate poisoned ones. A significant negative correlation was observed between AChE and severity of poisoning as well as significant positive correlation between CPK and lactate. It is concluded that serum CPK and serum lactate can be used as predictor of outcomes in OP poisoning and helps in determining cases that need follow up. Serum CPK and serum lactate can be used as predictors of outcomes in OP poisoning and helping in determining the cases that need follow up.

Key words: Organophosphrus poisoning, serum lactate, predicting prognosis, serum, admission.