Journal of Toxicology and Environmental Health Sciences
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Article Number - 7F36FAC771


Vol.1(1), pp. 012-021 , June 2009

ISSN: 2006-9820



Full Length Research Paper

Diclofenac induced toxic manifestations on adjuvant induced arthritic rats pheripheral and reproductive organ of male wistar rats rattus norvegicus


Sambandam Subramanian




Department of Biotechnology, International Research Institute for the Deaf (IRID), an Institute under Acoustical Foundation for Education and Charitable Trust (AFECT), Chennai, India


Email: sambandam.subramanian@gmail.com






 Accepted: 05 May 2009  Published: 30 June 2009

Copyright © 2009 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


Non-Steroidal Anti-inflammatory Drugs (NSAIDs) are the most frequently prescribed therapeutic agents, used for the treatment of rheumatic diseases, because they have analgesic, antipyretic and anti- inflammatory actions. Diclofenac (Voltaren) is a well-known member of the acetic acid family of NSAIDs, used to reduce inflammation and pain associated with arthritis osteoarthritis, and ankylosing spondylitis. There is considerable interest in the toxicity of diclofenac because of its clinical use and for the study of the mechanisms of nephrotoxicity, renal dysfunction, hematotoxicity and hypersensitivity reactions. In the present study we have reported the basic metabolites and activities of enzymes were studied in different tissues against adjuvant and diclofenac sodium treatment. The change due to the adjuvant treatment was attributed to the inflammation associated changes and the further alteration in diclofenac sodium was implicated to its toxic manifestation, besides the drug side effect is caused by metabolic idiosyncrasy.

 

Key words: Inflammation, adjuvant arthritis, metabolites, enzymes.


APA (2009). Diclofenac induced toxic manifestations on adjuvant induced arthritic rats pheripheral and reproductive organ of male wistar rats rattus norvegicus. Journal of Toxicology and Environmental Health Sciences, 1(1), 012-021.
Chicago Sambandam Subramanian. "Diclofenac induced toxic manifestations on adjuvant induced arthritic rats pheripheral and reproductive organ of male wistar rats rattus norvegicus." Journal of Toxicology and Environmental Health Sciences 1, no. 1 (2009): 012-021.
MLA Sambandam Subramanian. "Diclofenac induced toxic manifestations on adjuvant induced arthritic rats pheripheral and reproductive organ of male wistar rats rattus norvegicus." Journal of Toxicology and Environmental Health Sciences 1.1 (2009): 012-021.
   
DOI
URL http://academicjournals.org/journal/JTEHS/article-abstract/7F36FAC771

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