Journal of Toxicology and Environmental Health Sciences
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Article Number - 985893F47329


Vol.6(7), pp. 132-146 , September 2014
DOI: 10.5897/JTEHS2014.0312
ISSN: 2006-9820



Full Length Research Paper

Mitigating potential and antioxidant properties of aqueous seed extract of Leea guineensis against dichlorovos-induced toxicity in Wistar rats



Ajiboye B.O.*
  • Ajiboye B.O.*
  • Department of Chemical Sciences, Afe Babalola University, Ado-Ekiti, Nigeria
  • Google Scholar
Salawu S.O
  • Salawu S.O
  • Department of Biochemistry, Federal University, Akure, Ondo State, Nigeria.
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Okezie B
  • Okezie B
  • Department of Chemical Sciences, Afe Babalola University, Ado-Ekiti, Nigeria
  • Google Scholar
Oyinloye B.E.
  • Oyinloye B.E.
  • Department of Chemical Sciences, Afe Babalola University, Ado-Ekiti, Nigeria
  • Google Scholar
Ojo A.O.
  • Ojo A.O.
  • Department of Chemical Sciences, Afe Babalola University, Ado-Ekiti, Nigeria
  • Google Scholar
Onikanni S.A
  • Onikanni S.A
  • Department of Chemical Sciences, Afe Babalola University, Ado-Ekiti, Nigeria
  • Google Scholar
Oso A.O
  • Oso A.O
  • Department of Chemical Sciences, Afe Babalola University, Ado-Ekiti, Nigeria
  • Google Scholar
Asoso O.S
  • Asoso O.S
  • Department of Biological Sciences, Afe Babalola University, Ado-Ekiti, Nigeria.
  • Google Scholar
Obafemi T.O
  • Obafemi T.O
  • Department of Chemical Sciences, Afe Babalola University, Ado-Ekiti, Nigeria
  • Google Scholar







 Received: 29 July 2014  Accepted: 25 August 2014  Published: 30 September 2014

Copyright © 2014 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


 

This work was carried out to access the mitigating potential of Leea guineensis aqueous seed extract against dichlorovos (DDVP)-induced toxicity in Wistar rats for ten days. Twenty Wistar albino rats (weighing 90 to 106 g) were divided into four groups (Normal, DDVP-induced untreated, DDVP-induced treated with 200 mg/kg of L. guineensis seed and DDVP-induced treated with 400 mg/kg L. guineensis seed by oral gavage). DDVP was induced in the rats as a source of the main drinking water (5% v/v). The levels of malondialdehyde (MDA), total protein, albumin, bilirubin and the activities of glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were determined. The results revealed that exposure of rats to the pesticide water (DDVP) resulted in significant increase (p<0.05) in the levels of MDA and bilirubin with significant decrease (p<0.05) in the levels of total protein, albumin and the activities of GPx, CAT, SOD, ALT and AST, while administration with L. guineensis seed showed ameliorative effects in all biochemical parameters evaluated. This showed that treatment with aqueous seed extract of L. guineensis (200 and 400 mg/kg), most especially 400 mg/kg could ameliorate the biochemical indices related to liver toxicity in the animals.

 

Key words: Leea guineensis, dichlorovos, pesticide, antioxidant enzymes, oxidative stress.

 

 

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APA Ajiboye, B.O., Salawu, S.O., Okezie, B., Oyinloye, B.E., Ojo, A.O., Onikanni, S.A., Oso, A.O., Asoso, O.S. & Obafemi, T.O. (2014). Mitigating potential and antioxidant properties of aqueous seed extract of Leea guineensis against dichlorovos-induced toxicity in Wistar rats. Journal of Toxicology and Environmental Health Sciences, 6(7), 132-146.
Chicago   Ajiboye B.O., Salawu S.O., Okezie B., Oyinloye B.E., Ojo A.O., Onikanni S.A., Oso A.O., Asoso O.S. and Obafemi T.O.. "Mitigating potential and antioxidant properties of aqueous seed extract of Leea guineensis against dichlorovos-induced toxicity in Wistar rats." Journal of Toxicology and Environmental Health Sciences 6, no. 7 (2014): 132-146.
MLA Ajiboye B.O., et al. "Mitigating potential and antioxidant properties of aqueous seed extract of Leea guineensis against dichlorovos-induced toxicity in Wistar rats." Journal of Toxicology and Environmental Health Sciences 6.7 (2014): 132-146.
   
DOI 10.5897/JTEHS2014.0312
URL http://academicjournals.org/journal/JTEHS/article-abstract/985893F47329

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