Journal of
Toxicology and Environmental Health Sciences

  • Abbreviation: J. Toxicol. Environ. Health Sci.
  • Language: English
  • ISSN: 2006-9820
  • DOI: 10.5897/JTEHS
  • Start Year: 2009
  • Published Articles: 182

Full Length Research Paper

Mitigating potential and antioxidant properties of aqueous seed extract of Leea guineensis against dichlorovos-induced toxicity in Wistar rats

Ajiboye B.O.*
  • Ajiboye B.O.*
  • Department of Chemical Sciences, Afe Babalola University, Ado-Ekiti, Nigeria
  • Google Scholar
Salawu S.O
  • Salawu S.O
  • Department of Biochemistry, Federal University, Akure, Ondo State, Nigeria.
  • Google Scholar
Okezie B
  • Okezie B
  • Department of Chemical Sciences, Afe Babalola University, Ado-Ekiti, Nigeria
  • Google Scholar
Oyinloye B.E.
  • Oyinloye B.E.
  • Department of Chemical Sciences, Afe Babalola University, Ado-Ekiti, Nigeria
  • Google Scholar
Ojo A.O.
  • Ojo A.O.
  • Department of Chemical Sciences, Afe Babalola University, Ado-Ekiti, Nigeria
  • Google Scholar
Onikanni S.A
  • Onikanni S.A
  • Department of Chemical Sciences, Afe Babalola University, Ado-Ekiti, Nigeria
  • Google Scholar
Oso A.O
  • Oso A.O
  • Department of Chemical Sciences, Afe Babalola University, Ado-Ekiti, Nigeria
  • Google Scholar
Asoso O.S
  • Asoso O.S
  • Department of Biological Sciences, Afe Babalola University, Ado-Ekiti, Nigeria.
  • Google Scholar
Obafemi T.O
  • Obafemi T.O
  • Department of Chemical Sciences, Afe Babalola University, Ado-Ekiti, Nigeria
  • Google Scholar


  •  Received: 29 July 2014
  •  Accepted: 25 August 2014
  •  Published: 30 September 2014

Abstract

 

This work was carried out to access the mitigating potential of Leea guineensis aqueous seed extract against dichlorovos (DDVP)-induced toxicity in Wistar rats for ten days. Twenty Wistar albino rats (weighing 90 to 106 g) were divided into four groups (Normal, DDVP-induced untreated, DDVP-induced treated with 200 mg/kg of L. guineensis seed and DDVP-induced treated with 400 mg/kg L. guineensis seed by oral gavage). DDVP was induced in the rats as a source of the main drinking water (5% v/v). The levels of malondialdehyde (MDA), total protein, albumin, bilirubin and the activities of glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were determined. The results revealed that exposure of rats to the pesticide water (DDVP) resulted in significant increase (p<0.05) in the levels of MDA and bilirubin with significant decrease (p<0.05) in the levels of total protein, albumin and the activities of GPx, CAT, SOD, ALT and AST, while administration with L. guineensis seed showed ameliorative effects in all biochemical parameters evaluated. This showed that treatment with aqueous seed extract of L. guineensis (200 and 400 mg/kg), most especially 400 mg/kg could ameliorate the biochemical indices related to liver toxicity in the animals.

 

Key words: Leea guineensis, dichlorovos, pesticide, antioxidant enzymes, oxidative stress.