Journal of Toxicology and Environmental Health Sciences
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Article Number - E8529A064031


Vol.9(5), pp. 45-49 , May 2017
DOI: 10.5897/JTEHS2017.0386
ISSN: 2006-9820



Full Length Research Paper

Evaluation of occupational exposure to metal dust on the liver of road construction workers in Abuja metropolis


Ojevwe, D. D.1* and Osadolor, H. B.2




1Laboratory Unit, Maitama District Hospital, Abuja, Nigeria.

2Department of Medical Laboratory Science, University of Benin, Benin City, Edo State, Nigeria.


Email: ojesdave@yahoo.com






 Received: 28 February 2017  Accepted: 11 April 2017  Published: 31 May 2017

Copyright © 2017 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


Increasing air pollution levels due to rapid urbanization and growth in infrastructural facilities coupled with low level of standard safety procedures have been observed in Nigeria, and become a major source of concern. The study evaluated the effects of occupational exposure to metal dust on the liver of road construction workers in Abuja metropolis. Blood samples were used in the measurement of Lead, cadmium, magnesium and iron as indicators for metal toxicity. Bilirubin, liver enzymes (aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatise (ALP)) and proteins as biomarkers for liver function. Samples were collected from different road construction sites. One hundred (n = 100) subjects were recruited and served as the exposed group and another one hundred (n = 100) control as unexposed (control) group. Samples were analyzed using Atomic Absorption Spectrometry for the toxic metals (Lead and Cadmium) and trace elements (Magnesium and Iron); and Selectra ProS Clinical Chemistry Auto Analyzer for the liver function tests respectively. This study showed a statistically significant increase in Lead, Magnesium and Iron (p<0.001) when exposed subjects were compared with unexposed subjects. Test for liver function showed a significant reduction in total bilirubin (p<0.01) and direct bilirubin (p<0.05) respectively. Albumin also show statistically significant increase (p<0.05) on comparison of exposed and unexposed subjects. This study indicates the presence of metal dust in road construction workers occupationally exposed, and suggestive of liver impairment following continued exposure to these toxic metals and trace elements.

 

Key words: Occupational exposure, metal dust, liver.

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APA Ojevwe, D. D. & Osadolor, H. B. (2017). Evaluation of occupational exposure to metal dust on the liver of road construction workers in Abuja metropolis. Journal of Toxicology and Environmental Health Sciences, 9(5), 45-49.
Chicago Ojevwe, D. D. and Osadolor, H. B.. "Evaluation of occupational exposure to metal dust on the liver of road construction workers in Abuja metropolis." Journal of Toxicology and Environmental Health Sciences 9, no. 5 (2017): 45-49.
MLA Ojevwe, et al. "Evaluation of occupational exposure to metal dust on the liver of road construction workers in Abuja metropolis." Journal of Toxicology and Environmental Health Sciences 9.5 (2017): 45-49.
   
DOI 10.5897/JTEHS2017.0386
URL http://academicjournals.org/journal/JTEHS/article-abstract/E8529A064031

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