Journal of Veterinary Medicine and Animal Health
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Article Number - 5F085EF66309


Vol.9(11), pp. 313-319 , November 2017
https://doi.org/10.5897/JVMAH2017.0597
ISSN: 2141-2529


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Full Length Research Paper

Anthelmintic resistance in gastrointestinal nematodes of goats in southern Mozambique



Alsácia Atanásio-Nhacumbe
  • Alsácia Atanásio-Nhacumbe
  • School of Veterinary Medicine-Federal University of Bahia (UFBA), Av. Adhemar de Barros, 500, Ondina, Salvador-Bahia, CEP: 40.170-110, Brazil.
  • Google Scholar
Maria Consuêlo Carybé Ayres
  • Maria Consuêlo Carybé Ayres
  • School of Veterinary Medicine-Federal University of Bahia (UFBA), Av. Adhemar de Barros, 500, Ondina, Salvador-Bahia, CEP: 40.170-110, Brazil.
  • Google Scholar
Sabrina Mota Lambert
  • Sabrina Mota Lambert
  • School of Veterinary Medicine-Federal University of Bahia (UFBA), Av. Adhemar de Barros, 500, Ondina, Salvador-Bahia, CEP: 40.170-110, Brazil.
  • Google Scholar
Bárbara Paraná Souza
  • Bárbara Paraná Souza
  • School of Veterinary Medicine-Federal University of Bahia (UFBA), Av. Adhemar de Barros, 500, Ondina, Salvador-Bahia, CEP: 40.170-110, Brazil.
  • Google Scholar







 Received: 05 June 2017  Accepted: 25 July 2017  Published: 30 November 2017

Copyright © 2017 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


Small ruminant production is significantly constrained by gastrointestinal parasites once they cause serious production and economic losses for both small-scale and large-scale farmers in the developing world. The control of helminth parasites is most exclusively based on the use of anthelmintics for the economic production of ruminants. However, the resistance of nematodes to the commonly used groups of anthelmintics represents a threat to the production, particularly for small ruminants. The objective of this study was to assess the efficacy of albendazole, the most frequently used anthelmintic in Gaza and Maputo provinces in the southern region of Mozambique, in gastrointestinal nematodes of goats between November and December, 2016. Eleven goat farms in Gaza (n = 5) and Maputo (n = 6) were surveyed. The faecal egg count reduction test was used to assess the efficacy of the drug. The flocks were considered resistant when the reduction in eggs per gram of faeces was less than 95% and the lower limit of the confidence interval was less than 90%. Resistance to albendazole was detected in 60% (3/5) of the farms in Gaza province and 83.3% (5/6) of the farms in Maputo province. The percentage of faecal egg count reduction varied from 51 to 97% in Maputo and from 0 to 100% in Gaza in the farms surveyed. In pre-treatment coprocultures, Haemonchus spp., Oesophagostomum spp. and Trichostrongylus spp. were the predominant nematode species. Post-treatment larval cultures indicated that Haemonchus spp. and, to a lesser extent, Oesophagostomum spp. and Trichostrongylus spp., were resistant to albendazole. This study provided further evidence that anthelmintic resistance of gastrointestinal nematode parasites in goats is currently a problem of great significance in this region of the country and that appropriate measures must be taken to reverse the situation.

Key words: Albendazole, efficacy, gastrointestinal parasites, small ruminants, Mozambique.

kkari H, Jebali J, Gharbi M, Mhadhbi M, Awadi S, Darghouth MA (2013). Epidemiological study ofsympatric Haemonchus species and genetic characterization of Haemonchus contortus in domestic ruminants in Tunisia. Vet. Parasitol.193:118-125.
Crossref

 

Atanásio A, Boomker J, Sitoe C (2002). A survey on the occurrence of resistance to anthelmintics of gastrointestinal nematodes of goats in Mozambique. Onderstepoort J. Vet. Res. 69:215-220.

 
 

Borges SL, Oliveira AA, Mendonça LR, Lambert SM, Viana JM, Nishi SM, Julião FS, Almeida MAO (2015). Anthelmintic resistance in goat flocks from Caatinga and Mata Atlântica biomas.Pesq. Vet. Brasileira. 35:643-648.
Crossref

 
 

Burgess CGS, Bartley Y, Redman E, Skuce PJ, Nath M, Whitelaw F, Tait A, Gilleard JS, Jackson F (2012). A survey of the trichostrongylid nematode species present on UK sheep farms and associated anthelmintic control practices. Vet. Parasitol. 189:299-307.
Crossref

 
 

Canul-Ku HI, Rodriguéz-Vivas RI, Torres-Acosta JFJ, Aguilar-Caballero AJ, Perez-Cogollo LC, Ojeda-Chi MM (2012). Prevalence of cattle herds with ivermectin resistant nematodes in the hot sub-humid tropics of Mexico. Vet. Parasitol. 183:292-298.
Crossref

 
 

Chagas ACS, Katiki LM, Silva IC, Giglioti R, Esteves SN, Oliveira MC, Junior WB (2013). Haemonchus contortus: A multiple-resistant Brazilian isolate and the costs for its characterization and maintenance for research use. Parasitol. Int.62:1-6.
Crossref

 
 

Chaudhry U, Redman EM, Ramen M, Gillead JS (2015). Genetic evidence for the spread of a benzimidazole resistance mutation across southern India from a single origin in the parasite nematode Haemonchus contortus. Int. J. Parasitol. 45:721-728.
Crossref

 
 

Coles GC, Bauer C, Borgsteede FHM, Geerts S, Klei TR, Taylor MA, Waller P (1992). World Association for the Advancement of Veterinary Parasitology (W.A.A.VP) methods for the detection of anthelmintic resistance in nematodes of veterinary importance. Vet. Parasitol. 44:35-44.
Crossref

 
 

Coles GC, Jackson F, Pomroy WE, Prichard RK, von Samson-Himmelstjerna G, Silvestre A, Taylor MA, Vercruysse J (2006). The detection of anthelmintic resistance in nematodes of veterinary importance. Vet. Parasitol.136:167-185.
Crossref

 
 

Das Neves JH, Carvalho N, Rinaldi L, Cringoli G, Amarante AFT (2014). Diagnosis of anthelmintic resistance in cattle in Brazil: A comparison of different methodologies. Vet. Parasitol. 206:216-226.
Crossref

 
 

Diniz MA, Bandeira S, Eurico S, Martins ES (2012). Flora and Vegetation of Maputo province: Its appropriation by populations. Proceedings of International Congress on Tropical Knowledge in Mozambique: History, Memory and Science, IICT-JBT:1-2. Available at: 

View

 
 

FAO (2015). The Second Report on the State of the World's Animal Genetic Resources for Food and Agriculture [Scherf, B.D. and Pilling, D. (eds)]. FAO Commission on Genetic Resources for Food and Agriculture Assessments. Rome. Available at: 

View.

 
 

Gaba S, Cabaret J, Chylinski C, Sauve C, Cortet J, Silvestre A (2012). Can efficient management of sheep gastrointestinal nematodes of sheep be based on random treatment? Vet. Parasitol.190:178-184.
Crossref

 
 

Geary TG, Hosking BC, Skuce PJ, von Samson-Himmelstjerna G, Maeder S, Holdsworth P, Pomroy W, Vercruysse J, (2012). World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) Guideline: Anthelmintic combination products targeting nematode infections of ruminants and horses. Vet. Parasitol.190:306-316.
Crossref

 
 

Georgi JR, Theodorides VJ, Georgi ME (1985). Parasitology for Veterinarians. 4th Edition, Philadelphia: W.B. Saunders Company. Available at: 

View

 
 

Gupta SK, Singla LD (2012) Diagnostic trends in parasitic diseases of animals. In: Veterinary Diagnostics: Current Trends. Gupta RP, Garg SR, Nehra V and Lather D (Eds), Satish Serial Publishing House, Delhi. pp: 81-112.

 
 

Herrera-Manzanilla FA, Ojeda-Robertos NF, González-Gardu-o R, Cámara-Sarmiento R, Torres-Acosta JFJ (2017).Gastrointestinal nematode populations with multiple anthelmintic resistance in sheep farms from the hot humid tropics of Mexico. Vet. Parasitol. 9:29-33.
Crossref

 
 

Hussain T, Periasamy K, Nadeem A, Babar ME, Pichler R, Diallo A (2014). Sympatric species distribution, genetic diversityand population structure of Haemonchusisolates from domestic ruminants in Pakistan. Vet. Parasitol.206:188-199.
Crossref

 
 

Kenyon F, McBean D, Greer AW, Burgess GS, Morrison AA, Bartley DJ, Bartley Y, Davin L, Nath M, Jackson F (2013). A comparative study of the effects of four treatment regimens on ivermectin efficacy, body weight and pasture contamination in lambs naturally infected with gastrointestinal nematodes in Scotland. Int. J. Parasitol. Drugs Drug Resist. 3:77-84.
Crossref

 
 

Kumsa B, Abebe G (2009). Multiple anthelmintic resistance on a goat farm in Hawassa (southern Ethiopia). Trop. Anim. Health Prod. 41:655-662.
Crossref

 
 

Lira CMD (2005). 'Willow fodder blocks for growth and sustainable management of internal parasites ingrazinglambs', MSc Thesis, Massey University, New Zealand.

 
 

Martin PJ, Anderson N, Jarrett RG (1989). Detecting benzimidazole resistance with faecal egg count reduction tests and in vitro assays. Aust. Vet. J. 1989 66:236-240.
Crossref

 
 

McArthur MJ, Reinemeyer CR (2014). Herding the U.S. cattle industry towards a paradigm shift in parasite control. Vet. Parasitol. 204:34-43.
Crossref

 
 

McMahon C, Barley JP, Edgar HWJ, Ellison SE, Hanna REB, Malone FE, Brennan GP, Fairweather I (2013). Anthelmintic resistance in Northern Ireland II: Variations in nematode control practices between lowland and upland sheep flocks. Vet. Parasitol. 192:173-182.
Crossref

 
 

Pawar PD, Khasnis MW, Hong CD, Khole RP, Mhase PP, Singla LD (2017). Coproprevalence and successful management of parasitic infections in sheep in Pune district of Maharastra. Proceedings of 25th National Congress of Veterinary Parasitology and International Symposium on Current Concepts in Diagnosis & Control of Parasitic Diseases to Combat Climat Change (15-17 February, 2017) at Veterinary College, Shimoga. P 56.

 
 

Pena-Espinoza M, Thamsborg SM, Demeler J, Enemar KH (2014). Field efficacy of four anthelmintics and confirmation of drug-resistant nematodes by controlled efficacy test and pyrosequencing on a sheep and goat farm in Denmark. Vet. Parasitol. 206:208-215.
Crossref

 
 

Preston SJM, Sandeman M, Gonzalez J, Piedrafita D (2014). Current status for gastrointestinal nematode diagnosis in small ruminants: where are we and where are we going? J. Immunol. Res. 2014:1-12.
Crossref

 
 

Reinecke RK (1961). Helminth research in South Africa III. The diagnosis of nematode parasites in ruminants for worm survey purposes. J. South African Vet. Assoc.37:27-31.

 
 

Salgado JA, Santos CP (2016). Overview of anthelmintic resistance of gastrointestinal nematodes of small ruminants in Brazil. Rev. Brasileira Parasitol. Vet. 25(1):3-17.
Crossref

 
 

Shalaby HA (2013). Anthelmintic resistance; How to overcome it? Iranian J. Parasitol. 8:18-32.

 
 

Shija DSN, Kusiluka LJM, Chenyambuga SW, Shayo D, Lekule FP (2014). Animal health constraints in dairy goats kept under smallholder farming systems in Kongwa and Mvomero Districts, Tanzania. J. Vet. Med. Anim. Health 6(11):268-279.
Crossref

 
 

Singh E, Kaur P, Singla LD, Bal MS (2017a). Prevalence of gastrointestinal parasitism in small ruminants in western zone of Punjab, India. Vet. World 10(1):61-66.
Crossref

 
 

Singh R, Bal MS, Singla LD, Kaur P (2017b). Detection of anthelmintic resistance in sheep and goat against fenbendazole by faecal egg count reduction test. J. Parasitic Dis. 41(2):463-466.
Crossref

 
 

Sissay MM, Uggla A, Waller PJ (2007). Prevalence and seasonal incidence of nematode parasites and fluke infections of sheep and goats in eastern Ethiopia. Trop. Anim. Health Prod. 39:521-531.
Crossref

 
 

Ueno H, Gonçalves PC (1998). Handbook for diagnosis of helminthoses of ruminants. 4th Edition, Tokyo, JP: Japan International Cooperation, P 143. Available at: 

View

 
 

Van Wyk JA (2001). Refugia-overlooked as perhaps the most potent factor concerning the development of anthelmintic resistance. Onderstpoort J. Vet. Res.68:55-67.

 
 

Van Wyk, JA, Malan, FS, Randles, JL (1997). How long before resistance makes it impossible to control some field strains of Haemonchus contortus in South Africa with any of the modern anthelmintics?. Vet. Parasitol. 70:111-122.
Crossref

 
 

Wondimu A, Gutu S (2017). Gastrointestinal nematodes of small ruminants in Guto Gida District, East Wolloega, Ethiopia. J. Vet. Med. Anim. Health 9:83-87.
Crossref

 
 

Zvinorova PI, Halimani TE, Muchadeyi FC, Matika O, Riggio V, Dzama K (2016). Breeding for resistance to gastrointestinal nematodes- the potential in low-input/output small ruminant production systems. Vet. Parasitol. 225:19-28.
Crossref

 

 


APA Atanásio-Nhacumbe, A., Ayres, M. C. C., Lambert, S. M., & Souza, B. P. (2017). Anthelmintic resistance in gastrointestinal nematodes of goats in southern Mozambique. Journal of Veterinary Medicine and Animal Health, 9(11), 313-319.
Chicago Als&acia Atan&asio-Nhacumbe, Maria Consuêlo Caryb&e Ayres, Sabrina Mota Lambert and B&arbara Paran&a Souza. "Anthelmintic resistance in gastrointestinal nematodes of goats in southern Mozambique." Journal of Veterinary Medicine and Animal Health 9, no. 11 (2017): 313-319.
MLA Alsaacute;cia Atanaacute;sio-Nhacumbe, et al. "Anthelmintic resistance in gastrointestinal nematodes of goats in southern Mozambique." Journal of Veterinary Medicine and Animal Health 9.11 (2017): 313-319.
   
DOI https://doi.org/10.5897/JVMAH2017.0597
URL http://academicjournals.org/journal/JVMAH/article-abstract/5F085EF66309

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