Journal of Veterinary Medicine and Animal Health
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Article Number - C4F05EE834


Vol.1(1), pp. 11-016 , July 2009

ISSN: 2141-2529



Full Length Research Paper

Toxicological assessment of Cryptolepis sanguinolenta for possible use in veterinary medicine



C. Ansah
  • C. Ansah
  • Department of Pharmacology, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
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H. R. Otsyina
  • H. R. Otsyina
  • CSIR- Animal Research Institute, P.O. Box AH 20, Achimota, Accra, Ghana.
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M. Duwiejua
  • M. Duwiejua
  • Department of Pharmacology, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
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E. Woode
  • E. Woode
  • Department of Pharmacology, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
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F. A. Aboagye
  • F. A. Aboagye
  • Centre for Scientific Research into Plant Medicine, Mampong-Akwapim, Ghana
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K. G. Aning
  • K. G. Aning
  • College of Agriculture and Consumer Sciences, University of Ghana, Legon, Ghana.
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 Published: 30 July 2009

Copyright © 2009 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


 

Acute and sub-acute oral toxicity assessment of the aqueous root extract ofCryptolepis sanguinolenta was studied in Sprague Dawley rats for possible use as animal medication. The extract (250 - 3000 mg/kg, p.o) was administered daily for a period of 72 h and (500 - 2000 mg/kg, p.o) for 14 days for acute and sub-acute studies respectively.  Acute administration of the extract did not produce any physiological and behavioural changes. In the subacute toxicity studies however, a dose-dependent increase in the number of platelets (from a vehicle-treated control value of 353.00 ± 49.40 - 958.00 ± 42.50 in animals treated with 2000 mg/kg) was observed.  Granulocyte number also increased dose-dependently (0.77±0.15 - 3.70±0.20) from the vehicle-treated control to the group that received 2000 mg/kg, indicating possible inflammation.  Central nervous system toxicity and marginal enlargement of liver and kidney were evident in the 2000 mg/kg treated group. These findings however did not correlate with the biochemical and histopathological studies as no pathological changes occurred in the renal or hepato-biliary systems. The present results suggest that the aqueous root extract of C. sanguinolenta < 500 mg/kg orally is generally safe. However, caution should be taken with doses > 500 mg/kg as these may induce thrombocytosis, inflammation and central nervous system toxicity.

 

Key words:  Sub-acute toxicity, rats, Cryptolepis sanguinolenta extract.


APA (2009). Toxicological assessment of Cryptolepis sanguinolenta for possible use in veterinary medicine. Journal of Veterinary Medicine and Animal Health, 1(1), 11-016.
Chicago C. Ansah, H. R. Otsyina, M. Duwiejua, E. Woode, F. A.  Aboagye and K. G. Aning. "Toxicological assessment of Cryptolepis sanguinolenta for possible use in veterinary medicine." Journal of Veterinary Medicine and Animal Health 1, no. 1 (2009): 11-016.
MLA C. Ansah, et al. "Toxicological assessment of Cryptolepis sanguinolenta for possible use in veterinary medicine." Journal of Veterinary Medicine and Animal Health 1.1 (2009): 11-016.
   
DOI
URL http://academicjournals.org/journal/JVMAH/article-abstract/C4F05EE834

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