Journal of
Veterinary Medicine and Animal Health

  • Abbreviation: J. Vet. Med. Anim. Health
  • Language: English
  • ISSN: 2141-2529
  • DOI: 10.5897/JVMAH
  • Start Year: 2009
  • Published Articles: 311

Full Length Research Paper

Comparative efficacy of doxycycline and flumequine against experimentally induced colibacillosis in broiler chicks

Haji Akbar
  • Haji Akbar
  • Department of Biotechnology University of Malakand, Pakistan.National Center of Excellence in Molecular Biology, 87-west Canal Bank Road University of The Punjab Lahore.
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Murad Khan
  • Murad Khan
  • Department of Biotechnology University of Malakand, Pakistan.
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Ayaz Ali Khan
  • Ayaz Ali Khan
  • Department of Biotechnology University of Malakand, Pakistan.
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Muhammad Ali Khan
  • Muhammad Ali Khan
  • Department of Biotechnology University of Malakand, Pakistan.
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Muhammad Shuaib
  • Muhammad Shuaib
  • Department of Biotechnology University of Malakand, Pakistan.
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Shamaila Fazal Akbar
  • Shamaila Fazal Akbar
  • Zana Ultra Sound Clinic and Maternity Home, Swat Pakistan.
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Sobia Manzoor
  • Sobia Manzoor
  • National Center of Excellence in Molecular Biology, 87-west Canal Bank Road University of The Punjab Lahore.
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Irshad-ur-rehman
  • Irshad-ur-rehman
  • National Center of Excellence in Molecular Biology, 87-west Canal Bank Road University of The Punjab Lahore.
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Shakeel Ahmad
  • Shakeel Ahmad
  • Department of Biotechnology University of Malakand, Pakistan.
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Liaqat Ali
  • Liaqat Ali
  • National Center of Excellence in Molecular Biology, 87-west Canal Bank Road University of The Punjab Lahore.
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Rehmana Khalid
  • Rehmana Khalid
  • National Center of Excellence in Molecular Biology, 87-west Canal Bank Road University of The Punjab Lahore.
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Muhammad Idrees
  • Muhammad Idrees
  • National Center of Excellence in Molecular Biology, 87-west Canal Bank Road University of The Punjab Lahore.
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  • Article Number - D3032A6806
  • Vol.1(2), pp. 017-022, August 2009
  •  Accepted: 24 August 2009
  •  Published: 30 August 2009

Abstract

 

This study sought to determine comparative efficacy of doxycycline and flumequine for the treatment of colibacillosis, which is an acute septicaemic disease caused by pathogenic Escherichia coli. This disease has illness coming on in the range widely, death rate is relatively high and some are up to more than 30%, have caused the enormous economic losses. The birds were infected intra-peritoneally with approx. 3 × 10colony forming units per 0.25 ml of Enterotoxigenic E. coli (ETEC) and the infection developed within twelve hours. Chickens in group A1 were given doxycycline via the drinking water at a dose of 10 mg/kg body weight for 5 days, while group B1 was treated with flumequine at a dose of 12 mg/kg body weight for 5 days. The trial lasted for 9 days and then the surviving chickens were sacrificed. Doxycycline reduced the number of deaths and the severity of the clinical symptoms. In contrast, flumequine slightly influenced the mortality; however, it delayed death and reduced the severity of clinical symptoms. Present data indicate that doxycycline is highly effective for the treatment of experimental E. coli in chickens. The present study is of great importance for prescribing best effective drug against colibacillosis to avoid getting resistance to antibiotics.

 

Key words: Colibacillosis, doxycycline, flumequine, broilers.