Abstract

Lymphoma is the most common malignancy of the orbit and the eyelids, accounting for 10% of malignant orbital tumors in adults. Orbital lymphomas can arise primarily in the orbit or represent a manifestation of disseminated disease. In this paper we report a case of early stage orbital lymphoma, which was managed successfully with chemotherapy, and a review of the related literature. A Moroccan Muslim woman aged 76 years, who presented a left orbital swelling. Ophthalmological examination complemented by CT has objectified orbital mass, whose biopsy was in favour of a non Hodgkin's lymphoma (NHL) large cell B. The patient was classified as stage IE after a record expansion. She was managed successfully with 6 courses of Rituximab 375 mg/m², Cyclophosphamide 750 mg/m² d1, Doxorubicine 50 mg/m² d1, Vincristine 1.4 mg/m² d1, and prednisone 50 mg/m² d1-5 (R-CHOP) regimen, with complete response. This case highlights the important role of R-CHOP regimen for achieving successful treatment cure for patients having an early stage orbital lymphoma

Key words: Orbit, non hodgkin’s lymphoma, large cell, chemotherapy