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Article Number - BBBD259509

Vol.2(2), pp. 15-18 , February 2011

ISSN: 2141-6532


Kartagener’s syndrome- A case report

Jayita Poduval
  • Jayita Poduval
  • Department of Otolaryngology, Faculty of Medicine, AIMST University Semeling, Bedong-08100, Malaysia.
  • Google Scholar
Murali Poduval
  • Murali Poduval
  • Faculty of Medicine, AIMST University, Malaysia.
  • Google Scholar

 Accepted: 10 February 2011  Published: 28 February 2011

Copyright © 2011 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


Primary Ciliary Dyskinesia (PCD) is a genetic disorder with an autosomal recessive mode of inheritance.It is caused by a defect in the structure of cilia, due to which ciliary movement, and consequently, its function, are impaired.  Sinusitis, nasal polyposis, and otitis media with effusion are commonly seen among patients presenting to the otolaryngologist, and PCD should be considered as an aetiological factor in these cases, especially in the refractory ones. A case presenting to an otolaryngologist is described with a review of salient literature.


Key words: Nasal polyp, primary ciliary dyskinesia, Kartagener's syndrome.

Afzelius BA (2004). Cilia-related diseases. J. Pathol., 204: 470-477.
Afzelius BA (1976). A human syndrome caused by immotile cilia. Science, 193: 317-319.
Anthony M, Ho H, Friedland MJ (1992). Kartagener's Syndrome:anaesthetic considerations. Anaesthesiology; 77: 386-388.
Barker AF (2002). Bronchiectasis; Review Article; Medical Progress. N. Engl. J. Med., 346(18): 1383-1393.
Becker MD, Berkman YM, Fawwaz R, Van Heertum R (2000). Ga-67Scintigraphy showing the triad of bronchiectasis, paranasal sinusitis and situs inversus in a patient with Kartagener's Syndrome. Clin. Nuclear Med., 25(12): 1050-1051.
Bush A, Chodhari R, Collins N, Copeland F, Hall P, Harcourt J, HaririM, Hogg C, Lucas J, Mitchison HM, O'Callaghan C, Phillips G (2007). Primary ciliary dyskinesia: current state of the art. Review. Arch. Dis. Child., pp. 1136-1140.
PMid:17634184 PMCid:PMC2066071
Bush A, Payne D, Pike S, Jenkins G, Henke MO, Rubin BK (2006). Mucus properties in children with primary ciliary dyskinesia: comparison with cystic fibrosis. Chest, 129:118-123.
Bush A, Cole P, Hariri M, Mackay I, Phillips G, O'Callaghan C, Wilson R, Warner JO (1998). Primary ciliary dyskinesia: diagnosis and standards of care.Eur. Respir. J., 12: 982-988.
Canciani M, Barlocco EG, Mastella G, De Santi MM, Gardi C, Lungarella G (1988). The saccharin method of testing mucociliary function in patients suspected of having primary ciliary dyskinesia. Paediatr. Pulmonol., 5: 210-214.
Geremek M, Witt M (2004). Primary ciliary dyskinesia: genes, candidate genes and chromosomal regions. J. Appl. Genet., 45: 347-361.
Holmes LB, Blennerhasset JB, Austen KF (1964). A Reappraisal of Kartagener's Syndrome. Am. J. Med. Sci., pp. 13-28.
Jorissen M, Willems T, Van der Schueren B, Verbeken E, De Boeck K (2000). Ultrastructural expression of primary ciliary dyskinesia after ciliogenesis in culture. Acta Otorhinolaryngol. Belg., 54: 343-356.
Marsden D (1978). Nasal polyposis in children. Southern Med. J., 71(8): 911-913.
McManus C, Mitchison HM, Chung EMK, Stubbings GF, Martin N (2003). Primary ciliary dyskinesia (Siewert's /Kartagener's Syndrome):respiratory symptoms and psycho-social impact. BMC Pulm. Med., 3: 4.
PMid:14641928 PMCid:PMC317322
Narang I, Ersu R, Wilson NM, Bush A (2002). Nitric oxide in chronic airway inflammation in children: Diagnostic use and pathophysiological signs. Thorax, 57: 586-589.
PMid:12096200 PMCid:PMC1746369
Parsons DS, Greene BA (1993). A treatment for primary ciliary dyskinesia: Efficacy of functional endoscopic sinus surgery. Laryngoscope, 103: 1269-1272.
Stannard W, Rutman A, Wallis C, O'Callaghan C (2004). Central microtubular agenesis causing primary ciliary dyskinesia. Am J Respir. Crit. Care Med., 169: 634-637.
Teknos TN, Metson R, Chasse T, Ballercia G (1997). New developments in the diagnosis of Kartagener's Syndrome. Otolaryngol. Head Neck Surg., 116: 68-74.
Volsko T, Difiore J, Chatburn R (2003). Performance comparison of two oscillatory positive expiratory pressure devices: Acapella versus Flutter. Respir. Care, 48: 124-130.
Wodehouse T, Kharitonov SA, Mackay IS, Barnes PJ, Wilson R, Cole PJ (2003). Nasal nitric oxide measurements for the screening of primary ciliary dyskinesia, January. Eur. Respir. J., 21(1): 43-47.


APA (2011). Kartagener’s syndrome- A case report. Medical Case Studies, 2(2), 15-18.
Chicago Jayita Poduval and Murali Poduval. "Kartagener’s syndrome- A case report." Medical Case Studies 2, no. 2 (2011): 15-18.
MLA Jayita Poduval and Murali Poduval. "Kartagener’s syndrome- A case report." Medical Case Studies 2.2 (2011): 15-18.

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