Research in Pharmaceutical Biotechnology
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Article Number - 733D1AA454


Vol.2(1), pp. 007-013 , February 2010

ISSN: 2141-2324


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Full Length Research Paper

Potential therapeutic interventions on toll like receptors for clinical applications



Zhengwu Lu
  • Zhengwu Lu
  • 1006 S De Anza Blvd#K104, San Jose, CA 95129, USA.
  • Google Scholar







 Accepted: 30 October 2009  Published: 28 February 2010

Copyright © 2010 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


 

Toll like receptors (TLRs) function as pattern-recognition receptors (PRRs) and play key roles in the recognition of microbial components or endogenous ligands induced during inflammatory response. Studies on TLR-deficient mice have indicated TLRs' involvement in multiple pathologic conditions, and targeting of either the TLRs themselves or the signals they generate is proving to be of great interest to researchers as evidenced by increased research findings among immunologists, pharmacologist, and pharmaceutical scientists on TLRs. As animal models, cellular and molecular mechanisms on TLR mediated disease pathogenesis are made available, drug intervention strategies and early stage clinical studies can be planned and initiated to seek clinical proof for justifying TLRs and their associated signaling pathway/molecules as therapeutic targets. Moreover, a key functional output from TLRs is the generation of inflammatory cytokines such as tumor necrosis factor (TNF) and IL-6, which are excellent targets for inflammatory diseases such as rheumatoid arthritis.

 

Key words: TLR, PRR, NF-κB, agonist, antagonist, drug discovery.


APA (2010). Potential therapeutic interventions on toll like receptors for clinical applications. Research in Pharmaceutical Biotechnology, 2(1), 007-013.
Chicago Zhengwu Lu. "Potential therapeutic interventions on toll like receptors for clinical applications." Research in Pharmaceutical Biotechnology 2, no. 1 (2010): 007-013.
MLA Zhengwu Lu. "Potential therapeutic interventions on toll like receptors for clinical applications." Research in Pharmaceutical Biotechnology 2.1 (2010): 007-013.
   
DOI https://doi.org/
URL http://academicjournals.org/journal/RPB/article-abstract/733D1AA454

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