Research in Pharmaceutical Biotechnology
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Article Number - B06AC9955427


Vol.6(2), pp. 8-15 , September 2015
https://doi.org/10.5897/RPB2011. 030
ISSN: 2141-2324


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Full Length Research Paper

Evaluation of the in vivo anti malarial activity of the methanolic leaf extract of Nepata cateria



M. E. Khan*
  • M. E. Khan*
  • Department of Chemistry Adamawa State University, Mubi, Nigeria.
  • Google Scholar
J. O. Amupitan
  • J. O. Amupitan
  • Department of Chemistry Ahmadu Bello University, Zaria, Nigeria.
  • Google Scholar
A. O. Oyewale
  • A. O. Oyewale
  • Department of Chemistry Ahmadu Bello University, Zaria, Nigeria.
  • Google Scholar
I. G. Ndukwe
  • I. G. Ndukwe
  • Department of Chemistry Ahmadu Bello University, Zaria, Nigeria.
  • Google Scholar







 Received: 24 October 2011  Accepted: 25 August 2015  Published: 30 September 2015

Copyright © 2015 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


Nepata cateria (Labiatae) growing widely in northern Nigeria is used by most indigenes for the treatment of malaria and other related diseases. The in vivo anti-malarial activity of the methanol leaf extract was evaluated in mice infected with the chloroquine sensitive Plasmodium berghei berghei NK65 strain. Oral acute toxicity of the methanol leaf extract with modified Lorke`s method was evaluated against early, established, curative, prophylactic, and residual infections and their mean survival period studied. The oral median lethal dose of the extract in mice was determined to be about 3800 mg kg-1 body weight. The extract at doses of 100, 200 and 400 mg kg-1 body weight produced significant (P < 0.05) dose dependent activity against the parasites in the suppressive, curative and prophylactic tests. The results suggested that the methanol leaf fraction of N. cateria possesses anti-malarial activity and thus lends credence to its ethno medical and folkloric usage as malaria cure.

 

Key words: Nepata cateria, in vivo, Plasmodium berghei berghei, chloroquine, mice.

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APA Khan*, M. E., Amupitan, J. O., Oyewale, A. O., & Ndukwe, I. G. (2015). Evaluation of the in vivo anti malarial activity of the methanolic leaf extract of Nepata cateria. Research in Pharmaceutical Biotechnology, 6(2), 8-15.
Chicago M. E. Khan, J. O. Amupitan, A. O. Oyewale and I. G. Ndukwe  . "Evaluation of the in vivo anti malarial activity of the methanolic leaf extract of Nepata cateria." Research in Pharmaceutical Biotechnology 6, no. 2 (2015): 8-15.
MLA M. E. Khan, et al. "Evaluation of the in vivo anti malarial activity of the methanolic leaf extract of Nepata cateria." Research in Pharmaceutical Biotechnology 6.2 (2015): 8-15.
   
DOI https://doi.org/10.5897/RPB2011. 030
URL http://academicjournals.org/journal/RPB/article-abstract/B06AC9955427

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