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Article Number - C078BF743689


Vol.5(1), pp. 1-6 , March 2014
https://doi.org/DOI: 10.5897/RPB13.0088
ISSN: 2141-2324


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Full Length Research Paper

Synthesis, characterization and biological activity of 2-Aryl -2, 3-dihydro-1H-perimidine



Kezhal M. Salih
  • Kezhal M. Salih
  • Department of Pharmaceutical Chemistry, College of Pharmacy, Hawler Medical University, Erbil, Iraq
  • Google Scholar
Hashim J. Azeez
  • Hashim J. Azeez
  • Department of Chemistry, College of Education, Salahaddin University, Erbil, Iraq
  • Google Scholar







 Received: 18 September 2013  Accepted: 28 February 2014  Published: 31 March 2014

Copyright © 2014 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


A series of new 2-Aryl-2,3-dihydro-1H-perimidine, derivatives (3a - j) were synthesized under reflux and at room temperature by condensation reaction of 1,8-diaminonaphthalene (2) with various substituted benzaldehyde using glacial acetic acid a catalyst. The synthesized compounds were characterized by spectroscopic methods, infrared (IR), proton nuclear magnetic resonance (1H-NMR), carbon nuclear magnetic resonance (13C-NMR) and carbon nuclear magnetic resonance-distortionless enhancement by polarization (13C-NMR-DEPT). The synthesized compounds were screened for their biological activity against the Gram-positive bacteria Staphylococcus aureus and the Gram-negative bacteria Escherichia coli. The results showed that 89% of the synthesized compounds were not active against S. aureus, while E. coli showed 100% sensitivity to the mentioned compound. These results illustrate the marked bactericidal effect of all the synthesized compounds. 
 
Key words: 1, 8-Diaminonaphthalene, 2,3-dihyroperimidin, perimidine.
 

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APA Hashim, J.A & Kezhal, MS (2014). Synthesis, characterization and biological activity of 2-Aryl -2, 3-dihydro-1H-perimidine. Research in Pharmaceutical Biotechnology, 5(1), 1-6.
Chicago Hashim J. Azeez and Kezhal M. Salih. "Synthesis, characterization and biological activity of 2-Aryl -2, 3-dihydro-1H-perimidine." Research in Pharmaceutical Biotechnology 5, no. 1 (2014): 1-6.
MLA Hashim J. Azeez and Kezhal M. Salih. "Synthesis, characterization and biological activity of 2-Aryl -2, 3-dihydro-1H-perimidine." Research in Pharmaceutical Biotechnology 5.1 (2014): 1-6.
   
DOI https://doi.org/DOI: 10.5897/RPB13.0088
URL http://academicjournals.org/journal/RPB/article-abstract/C078BF743689

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