Research in Pharmaceutical Biotechnology

  • Abbreviation: Res. Pharm. Biotech.
  • Language: English
  • ISSN: 2141-2324
  • DOI: 10.5897/RPB
  • Start Year: 2009
  • Published Articles: 42

Full Length Research Paper

Synthesis, characterization and biological activity of 2-Aryl -2, 3-dihydro-1H-perimidine

Kezhal M. Salih
  • Kezhal M. Salih
  • Department of Pharmaceutical Chemistry, College of Pharmacy, Hawler Medical University, Erbil, Iraq
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Hashim J. Azeez
  • Hashim J. Azeez
  • Department of Chemistry, College of Education, Salahaddin University, Erbil, Iraq
  • Google Scholar


  •  Received: 18 September 2013
  •  Accepted: 28 February 2014
  •  Published: 31 March 2014

Abstract

A series of new 2-Aryl-2,3-dihydro-1H-perimidine, derivatives (3a - j) were synthesized under reflux and at room temperature by condensation reaction of 1,8-diaminonaphthalene (2) with various substituted benzaldehyde using glacial acetic acid a catalyst. The synthesized compounds were characterized by spectroscopic methods, infrared (IR), proton nuclear magnetic resonance (1H-NMR), carbon nuclear magnetic resonance (13C-NMR) and carbon nuclear magnetic resonance-distortionless enhancement by polarization (13C-NMR-DEPT). The synthesized compounds were screened for their biological activity against the Gram-positive bacteria Staphylococcus aureus and the Gram-negative bacteria Escherichia coli. The results showed that 89% of the synthesized compounds were not active against S. aureus, while E. coli showed 100% sensitivity to the mentioned compound. These results illustrate the marked bactericidal effect of all the synthesized compounds. 
 
Key words: 1, 8-Diaminonaphthalene, 2,3-dihyroperimidin, perimidine.