Research in Pharmaceutical Biotechnology
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Article Number - D29FAE0493


Vol.4(1), pp. 1-5 , March 2012
https://doi.org/10.5897/RPB11.031
ISSN: 2141-2324


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Full Length Research Paper

Evaluation of Sesamum indicum gum as a binder in the formulation of paracetamol granules and tablets



Peace Ubulom
  • Peace Ubulom
  • Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Uyo, Akwa Ibom State, Nigeria.
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Romanus Umoh
  • Romanus Umoh
  • Department of Pharmacognosy and Natural Medicine, Faculty of Pharmacy, University of Uyo, Akwa Ibom State, Nigeria.
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Musiliu Adedokun
  • Musiliu Adedokun
  • Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Uyo, Akwa Ibom State, Nigeria.
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Ekaette Akpabio
  • Ekaette Akpabio
  • Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Uyo, Akwa Ibom State, Nigeria.
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Clement Jackson
  • Clement Jackson
  • Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Uyo, Akwa Ibom State, Nigeria.
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Godwin Ekpe
  • Godwin Ekpe
  • Department of Clinical Pharmacy and Biopharmacy, Faculty of Pharmacy, University of Uyo, Akwa Ibom State, Nigeria.
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 Accepted: 12 January 2012  Published: 30 March 2012

Copyright © 2012 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


 

Comparative evaluation of Sesamum indicum gum as a binder in the formulation of paracetamol (PCM) granules and tablets was performed using acacia, gelatin, and Sodium carboxyl methylcellulose (SCMC) as standard binders for comparison. The properties of granules and tablets such as; flow rate, angle of repose, density, weight uniformity, crushing strength, friability, disintegration rate and release profiles, were evaluated. The compact granules had good flow properties. However, binder concentration influenced flow characteristics. SIG gave the highest hardness/friability ratios. It also prolonged disintegration and dissolution time and dissolution rate. Hence, SIG may not be useful as a binder in conventional tablet formulation but may serve as a binder or hydrophilic polymer in sustained release tablet formulation.

 

Key words: Sesamum indicum gum, binder, paracetamol tablets.


APA (2012). Evaluation of Sesamum indicum gum as a binder in the formulation of paracetamol granules and tablets. Research in Pharmaceutical Biotechnology, 4(1), 1-5.
Chicago Clement Jackson⊃, Ekaette Akpabio⊃, Romanus Umoh⊃, Musiliu Adedokun⊃, ⊃Peace Ubulom and Godwin Ekpe⊃. "Evaluation of Sesamum indicum gum as a binder in the formulation of paracetamol granules and tablets." Research in Pharmaceutical Biotechnology 4, no. 1 (2012): 1-5.
MLA Clement Jacksonsup;, et al. "Evaluation of Sesamum indicum gum as a binder in the formulation of paracetamol granules and tablets." Research in Pharmaceutical Biotechnology 4.1 (2012): 1-5.
   
DOI https://doi.org/10.5897/RPB11.031
URL http://academicjournals.org/journal/RPB/article-abstract/D29FAE0493

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