Research in Pharmaceutical Biotechnology

  • Abbreviation: Res. Pharm. Biotech.
  • Language: English
  • ISSN: 2141-2324
  • DOI: 10.5897/RPB
  • Start Year: 2009
  • Published Articles: 42

Full Length Research Paper

Evaluation of Sesamum indicum gum as a binder in the formulation of paracetamol granules and tablets

Peace Ubulom
  • Peace Ubulom
  • Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Uyo, Akwa Ibom State, Nigeria.
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Romanus Umoh
  • Romanus Umoh
  • Department of Pharmacognosy and Natural Medicine, Faculty of Pharmacy, University of Uyo, Akwa Ibom State, Nigeria.
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Musiliu Adedokun
  • Musiliu Adedokun
  • Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Uyo, Akwa Ibom State, Nigeria.
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Ekaette Akpabio
  • Ekaette Akpabio
  • Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Uyo, Akwa Ibom State, Nigeria.
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Clement Jackson
  • Clement Jackson
  • Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Uyo, Akwa Ibom State, Nigeria.
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Godwin Ekpe
  • Godwin Ekpe
  • Department of Clinical Pharmacy and Biopharmacy, Faculty of Pharmacy, University of Uyo, Akwa Ibom State, Nigeria.
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  •  Accepted: 12 January 2012
  •  Published: 30 March 2012

Abstract

 

Comparative evaluation of Sesamum indicum gum as a binder in the formulation of paracetamol (PCM) granules and tablets was performed using acacia, gelatin, and Sodium carboxyl methylcellulose (SCMC) as standard binders for comparison. The properties of granules and tablets such as; flow rate, angle of repose, density, weight uniformity, crushing strength, friability, disintegration rate and release profiles, were evaluated. The compact granules had good flow properties. However, binder concentration influenced flow characteristics. SIG gave the highest hardness/friability ratios. It also prolonged disintegration and dissolution time and dissolution rate. Hence, SIG may not be useful as a binder in conventional tablet formulation but may serve as a binder or hydrophilic polymer in sustained release tablet formulation.

 

Key words: Sesamum indicum gum, binder, paracetamol tablets.