Research in Pharmaceutical Biotechnology
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Article Number - DB57CAD451


Vol.1(1), pp. 001-008 , November 2009

ISSN: 2141-2324


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Full Length Research Paper

Neuropharmacological effects of Sorghum bicolor leaf base extract



F. C. Nwinyi
  • F. C. Nwinyi
  • Department of Pharmacology and Clinical Pharmacy, Ahmadu Bello University Main Campus, P. M. B. 1045, Zaria 810271, Kaduna State, Nigeria.
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H. O. Kwanashie
  • H. O. Kwanashie
  • Department of Pharmacology and Clinical Pharmacy, Ahmadu Bello University Main Campus, P. M. B. 1045, Zaria 810271, Kaduna State, Nigeria.
  • Google Scholar







 Accepted: 28 September 2009  Published: 30 November 2009

Copyright © 2009 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


 

The neuropharmacological effects of aqueous methanolic extract of leaf base ofSorghum bicolor were studied on Wistar rats and Swiss albino mice; evaluations were done on spontaneous motor activity, exploratory behaviour, apomorphine-induced stereotypic behaviour, pentobarbitone sleeping time and rota-rod performance for motor coordination. The results showed a significant (P < 0.05) reduction in the spontaneous motor activity. The treated animals exhibited: (i) A reduction in the exploratory behaviour as did diazepam (1 mg/kg i.p.); (ii) No change in Apomorphine-induced stereotypic behaviour; (iii) Prolonged pentobarbitone-induced sleep as did diazepam (1 mg/kg i.p.) and cimetidine (100 mg/kg p.o) and no significant (P < 0.05) effect on rota-rod performance for motor coordination. These findings suggest that leaf base extracts of S. bicolor contains sedative substances that act via centrally-mediated actions rather than peripheral neuromuscular blockade and may also be microsomal enzyme inhibitor like cimetidine.

 

Key words: Sorghum bicolor, spontaneous motor activity, exploratory behaviour, stereotype behaviour, pentobarbitone sleep, motor coordination.


APA (2009). Neuropharmacological effects of Sorghum bicolor leaf base extract. Research in Pharmaceutical Biotechnology, 1(1), 001-008.
Chicago F. C.  Nwinyi and H. O. Kwanashie. "Neuropharmacological effects of Sorghum bicolor leaf base extract." Research in Pharmaceutical Biotechnology 1, no. 1 (2009): 001-008.
MLA F. C.  Nwinyi and H. O. Kwanashie. "Neuropharmacological effects of Sorghum bicolor leaf base extract." Research in Pharmaceutical Biotechnology 1.1 (2009): 001-008.
   
DOI https://doi.org/
URL http://academicjournals.org/journal/RPB/article-abstract/DB57CAD451

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