Research in Pharmaceutical Biotechnology

  • Abbreviation: Res. Pharm. Biotech.
  • Language: English
  • ISSN: 2141-2324
  • DOI: 10.5897/RPB
  • Start Year: 2009
  • Published Articles: 42

Full Length Research Paper

Neuropharmacological effects of Sorghum bicolor leaf base extract

F. C. Nwinyi
  • F. C. Nwinyi
  • Department of Pharmacology and Clinical Pharmacy, Ahmadu Bello University Main Campus, P. M. B. 1045, Zaria 810271, Kaduna State, Nigeria.
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H. O. Kwanashie
  • H. O. Kwanashie
  • Department of Pharmacology and Clinical Pharmacy, Ahmadu Bello University Main Campus, P. M. B. 1045, Zaria 810271, Kaduna State, Nigeria.
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  • Article Number - DB57CAD451
  • Vol.1(1), pp. 001-008, November 2009
  •  Accepted: 28 September 2009
  •  Published: 30 November 2009

Abstract

 

The neuropharmacological effects of aqueous methanolic extract of leaf base ofSorghum bicolor were studied on Wistar rats and Swiss albino mice; evaluations were done on spontaneous motor activity, exploratory behaviour, apomorphine-induced stereotypic behaviour, pentobarbitone sleeping time and rota-rod performance for motor coordination. The results showed a significant (P < 0.05) reduction in the spontaneous motor activity. The treated animals exhibited: (i) A reduction in the exploratory behaviour as did diazepam (1 mg/kg i.p.); (ii) No change in Apomorphine-induced stereotypic behaviour; (iii) Prolonged pentobarbitone-induced sleep as did diazepam (1 mg/kg i.p.) and cimetidine (100 mg/kg p.o) and no significant (P < 0.05) effect on rota-rod performance for motor coordination. These findings suggest that leaf base extracts of S. bicolor contains sedative substances that act via centrally-mediated actions rather than peripheral neuromuscular blockade and may also be microsomal enzyme inhibitor like cimetidine.

 

Key words: Sorghum bicolor, spontaneous motor activity, exploratory behaviour, stereotype behaviour, pentobarbitone sleep, motor coordination.