The latex of Himatanthus sucuuba (Spruce) Woodson, used popularly in the Amazon for the treatment of tumors, gastritis, inflammations and infections, was evaluated for cytotoxicity and antibacterial activities. The iridoid lactones, plumericin and isoplumericin were isolated from latex by bioassay fractionation and were found to be associated with DNA damage. Gallic acid exhibited the highest antimicrobial activity among the phenolic compounds isolated from the aqueous fraction. The compounds associated to cytotoxicity and antimicrobial activities could be responsible to the effects of this species used in traditional medicine.
Key words: Himatanthus sucuuba, iridoids, phenolics, cytotoxicity, antibacterial.
TLC, Thin layer chromatography; MIC, minimum inhibitory concentration; IC12, concentration (µg/ml) is required to produce a zone of inhibition of 12 mm; MeOH, methanol; EtOAc, ethyl ethanoate; n-BuOH, n-butanol; GC/MS,gas chromatography coupled with mass spectrophometer; NMR, nuclear magnetic resonance; MPLC, medium pressure liquid chromatography.
Copyright © 2020 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0