African Journal of

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12179

Full Length Research Paper

Extracted tetrodotoxin from puffer fish Lagocephalus lagocephalus induced hepatotoxicity and nephrotoxicity to Wistar rats

Mongi Saoudi1,2*, Mahfoud Messarah3, Amel Boumendjel3, Abdelwaheb Abdelmouleh2, Wassim Kammoun2, Kamel  Jamoussi4 and Abdelfattah El Feki1
1Animal Ecophysiology Laboratory, Sciences Faculty of Sfax, Tunisia. 2Marine Biotechnology and Biodiversity Laboratory, INSTM of Sfax, Tunisia. 3Animal Ecophysiology Laboratory, Sciences Faculty of Badji Mokhtar University, BP 12 Sidi Amar, Annaba, Algeria. 4Biochemistry Laboratory, CHU Habib Bourguiba of Sfax, Tunisia.
Email: [email protected]

  •  Accepted: 29 April 2011
  •  Published: 03 August 2011


This study aimed to investigate the toxicity of raw and boiled tissue extracts ofLagocephalus lagocephalus flesh or liver. Five groups of six male Wistar rats each were used. Four groups received a daily intraperitoneal injection of raw or boiled tissue extracts of L. lagocephalus flesh and liver at a dose of 1 ml/100 g (v/w). The fifth group served as a sham and received a daily intraperitoneal injection of saline solution (1 ml/100 g of 0.9% NaCl, v/w). During the experiment, there was a slight decrease in body weight in all treated groups. Our results revealed that the activities of various enzymes like transaminase, alkaline phosphatase (ALP), gamma glutamyl transpeptidase (γ-GT) and lactate dehydrogenase (LDH) decreased in serum and increased in liver and kidney tissues, producing hepatotoxicity and nephrotoxicity in the treated rats. These observations on the toxicity of this Tunisian puffer fish revealing toxicity especially in the flesh, the edible part of fish, clearly indicate the danger of using this fish as food.


Key words: Hepatotoxicity, Lagocephalus lagocephalus, nephrotoxicity.

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