Abstract

The aim of the study was to evaluate the effect of Salvia officinalis leaf extract in overdosed-tramadol induced rats.  Standard methods of analysis were used for the study. Fifty rats were divided into Group A (Control) - feed and water only, Group B-induced with tramadol at 50 mg/kg body weight, Group C-induced with tramadol + 150 mg/kg of S. officinalis leaf extract, Group D-tramadol + 300 mg/kg S. officinalis leaf extract, and Group E-tramadol + 400 mg/kg S. officinalis leaf extract. The results showed high concentrations of phytochemical and trace elements at various concentrations. There were increases in aspartate amino transaminase, alanine aminotransferase, gamma gluamyltransferase, alkaline phosphatase and in total protein, albumin, total bilirubin, conjugated bilirubin, sodium, potassium, chloride, bicarbonate, urea, calcium, creatinine, total cholesterol, magnesium, hemoglobin, packed cell volume, and total white blood cell count at a significant difference (p ? 0.05) in Group B when compared with Group A. However, in Groups C, D and E, there was statistically significant decrease (p ? 0.05) in aspartate amino transaminase, alanine aminotransferase, gamma gluamyltransferase, alkaline phosphatase and total protein, albumin, total bilirubin, conjugated bilirubin, sodium, potassium, chloride, bicarbonate, urea, calcium, creatinine, total cholesterol and magnesium compared with the Group B. The study showed that S. officinalis leaf could be of an unalloyed health benefits in the management of tramadol-induced toxicity in rats.

Key words: Tramadol, Sage, phytochemicals/elements, markers, rats.