African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12294

Full Length Research Paper

Antiglycation Activity of Otostegia persica (Burm.) Boiss

Seyed Abdul Majid Ayatollahi1,2 , Farzad Kobarfard1,3 , Jinous Asgarpanah4*and Muhammad Iqbal Choudhary5
1Phytochemistry Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran 2Department of Pharmacognosy, 3Department of Medicinal Chemistry, School of Pharmacy, Shaheed Beheshti University of Medical Sciences, Tehran, Iran. 4Department of Pharmacognosy, Pharmaceutical Sciences Branch, Islamic Azad University (IAU), Tehran, Iran 5H.E.J. Research Institute of Chemistry University of Karachi, 75270-Karachi, Pakistan
Email: [email protected]

  •  Accepted: 12 April 2010
  •  Published: 14 June 2010

Abstract

 Diabetes mellitus is a common endocrine disorder characterized by hyperglycemia and long-term complications affecting the eyes, nerves, blood vessels, skin and kidneys. Increased glycation of proteins and accumulation of advanced glycation endproducts (AGEPs) have been implicated in the pathogenesis of diabeticcomplications. Glycation and AGEP formation are also accompanied by the formation of free radicals via autoxidation of glucose and glycated proteins. Compounds with combined antiglycation and antioxidant properties may offer therapeutic potential. Since the antioxidant activity of different extracts and fractions of aerial parts of Otostegia persica has been evaluated and this plant is used as an antidiabetic agent in Iranian traditional medicine, we evaluated the antiglycation activity of this species. Here, we report the isolation of known compound 3´, 7-dihydroxy-4´,6,8-trimethoxy-flavone for the antiglycation properties of this plant.

 

Key words: Antiglycation, Otostegia persica, 3’,7-dihydroxy-4’,6,8-trimethoxy-flavone. 

Abbreviation

DMSO, Dimethyl sulfoxide; BSA, bovine serum albumin; TCA, trichloroacetic acid; AGEs, advanced glycation endproducts.