Abstract

 Diabetes mellitus is a common endocrine disorder characterized by hyperglycemia and long-term complications affecting the eyes, nerves, blood vessels, skin and kidneys. Increased glycation of proteins and accumulation of advanced glycation endproducts (AGEPs) have been implicated in the pathogenesis of diabeticcomplications. Glycation and AGEP formation are also accompanied by the formation of free radicals via autoxidation of glucose and glycated proteins. Compounds with combined antiglycation and antioxidant properties may offer therapeutic potential. Since the antioxidant activity of different extracts and fractions of aerial parts of Otostegia persica has been evaluated and this plant is used as an antidiabetic agent in Iranian traditional medicine, we evaluated the antiglycation activity of this species. Here, we report the isolation of known compound 3´, 7-dihydroxy-4´,6,8-trimethoxy-flavone for the antiglycation properties of this plant.

Key words: Antiglycation, Otostegia persica, 3’,7-dihydroxy-4’,6,8-trimethoxy-flavone. 

Abbreviation

DMSO, Dimethyl sulfoxide; BSA, bovine serum albumin; TCA, trichloroacetic acid; AGEs, advanced glycation endproducts.