African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12191

Short Communication

Hepatoprotective effect of Picrorrhiza kurroa on antioxidant defense system in antitubercular drugs-induced hepatotoxicity in rats

R. Jeyakumar1, R. Rajesh1, D. Rajaprabhu1, B. Ganesan1,2, S. Buddhan1, R. Anandan2*
  1Vinayaka Missions University, Ariyanoor, Salem-636308, India. 2Biochemistry and Nutrition Division, Central Institute of Fisheries Technology, Cochin-682029, India.
Email: [email protected]

  •  Accepted: 09 January 2008
  •  Published: 06 April 2009

Abstract

 

The hepatoprotective effect of the ethanol extract of Picrorrhiza kurroa rhizomes and roots (PK) on liver mitochondrial antioxidant defense system in isoniazid and rifampicin-induced hepatitis in rats was investigated. In liver mitochondria of antitubercular drugs administered rats, a significant elevation in the level of lipid peroxidation with concomitant decline in the level of reduced glutathione and in the activities of antioxidant enzymes was observed. Co-administration of PK (50 mg/kg/day for 45 days) significantly prevented these antitubercular drugs-induced alterations and maintained the rats at near normal status.

 

Key words: Picrorrhiza kurroa, hepatoprotective activity.