African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12254

Full Length Research Paper

In vitro antimicrobial properties of friedelan-3-one from Pterocarpus santalinoides L’Herit, ex Dc

Ichiko Chic Ode
  • Ichiko Chic Ode
  • College of Education, Oju, Benue State, Nigeria.
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Terrumun Amom Tor-Anyiin
  • Terrumun Amom Tor-Anyiin
  • Department of Chemistry, Federal University of Agriculture, Makurdi, Nigeria.
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John Ogbaji Igoli
  • John Ogbaji Igoli
  • Department of Chemistry, Federal University of Agriculture, Makurdi, Nigeria.
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John Vershima Anyam
  • John Vershima Anyam
  • Department of Chemistry, Federal University of Agriculture, Makurdi, Nigeria.
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  •  Received: 08 November 2015
  •  Accepted: 25 February 2016
  •  Published: 06 April 2016

Abstract

Chemical investigation of ethyl acetate leaf-extract of Pterocarpus santalinoides led to isolation of a friedelane-terpenoid. Structure elucidation was done by comparison of the Nuclear Magnetic Resonance (NMR) spectral features with literature data and was consistent with reported values for friedelan-3-one. The following microorganisms (Clinical isolates): methicillin resistant Staphylococcus aureus (MRSA), S. aureus, Corynebacterium ulcerans, Streptococcus pneumoniae, Campylobacter jejuni, Helicobacter pylori, Escherichia coli, Shigella dysenteriae, Candida tropicalis and Candida krusei were used for the in vitro  antimicrobial activity. The isolated compound had Minimum Inhibition Concentration (MIC) value of 10 µg/ml for MRSA, H. pylori, E. coli and Minimum Bactericidal/Fungicidal Concentration (MBC/MFC) of 40 µg/ml for E. coli; 20 µg/ml for MRSA, H. pylori and C. krusei; 10 µg/ml for S. aureus, S. pneumonia and C. tropicalis. It showed moderate antimicrobial activity against most of the pathogens tested. This is also the first report of the isolation of friedelan-3-one from this species.

Key words: Friedelan-3-one, methicillin resistant Staphylococcus aureus (MRSA), Helicobacter pylori, Escherichia coli.