The objective of this study was to design nano-antibiotic to enhance their release from biomaterial agents. Cefotaxime was used as a model antibiotic substance in this carrier system. These nanoparticles were preformulated using different concentrations of polycaprolactone (PCL) and poly (vinyl alcohol) as coating material and prepared using double emulsion solvent evaporation method. The physiochemical properties of cefotaxime nano-antibiotic (Cefo-NPs) stability were determined. Results showed that the encapsulation efficiency of nanoparticles increased with increase in polymer concentration. In addition, dynamic light scattering (DLS) and atomic force microscope (AFM) indicated that the particles size were in the range of 189 to 219 nm. The drug release profile of Cefo-NPs shows rapidly the release behaviour under acidic environment. And thus make it a promising tool for control bacterial infection.
Key words: Polycaprolactone, poly (vinyl alcohol), cefotaxime, nanoparticle.
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