African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12370

Full Length Research Paper

Antioxidative and anti-aging activities of Abeliophyllum distichum Nakai extracts fermented with lactobacillus plantarum and lactobacillus brevis

KiBeom Lee
  • KiBeom Lee
  • Bioindustry Center, Incheon Technopark, 12 Gaetbeol-ro, Yeonsu-gu, Incheon, South Korea.
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Ju Hyun Park
  • Ju Hyun Park
  • Genetrone Biotech Co., Ltd, 2F, 4F, Sehyun Building, 15 Hongsanbuk-ro, Wansan-gu, Jeonju-si Jeollabuk-do, South Korea.
  • Google Scholar
Yun Sung Kim
  • Yun Sung Kim
  • Genetrone Biotech Co., Ltd, 2F, 4F, Sehyun Building, 15 Hongsanbuk-ro, Wansan-gu, Jeonju-si Jeollabuk-do, South Korea.
  • Google Scholar


  •  Received: 19 July 2021
  •  Accepted: 24 September 2021
  •  Published: 31 October 2021

Abstract

Abeliophyllum distichum Nakai is a deciduous shrub that belongs to Oleaceae Abeliophyllum and grows only in Korea. In this study, the antioxidative activity, cytotoxicity, anti-aging activity, and levels of acteoside and isoacteoside were compared between non-fermented and fermented (using Lactobacillus plantarum and Lactobacillus brevis) extracts of A. distichum Nakai. The cytotoxicity of these extracts, along with their ability to inhibit elastase activity and Matrix metalloproteinase-1 (MMP-1) expression, and their ability to promote type I procollagen synthesis were investigated in human dermal fibroblasts cells. These tests revealed that the fermented extract possessed higher antioxidant and anti-aging activities compared with the non-fermented extract. The levels of acteoside and isoacteoside were about 1.25 and 1.05 times higher in the fermented extract than in the non-fermented extract. It was speculated that they were converted from acteoside glucosides and isoacteoside glucosides via bioconversion by the fermentation strains. Together, these findings indicate that extracts of A. distichum Nakai show good potential as antioxidative and anti-aging cosmetic materials.

 

Key words: Abeliophyllum distichum Nakai, Lactobacillus plantarum, Lactobacillus brevis, fermentation, antioxidative activity, anti-aging activity.