African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12227

Full Length Research Paper

Comparative effects of some medicinal plants on blood glucose concentration and lipid levels in alloxan-induced diabetic rats

GOMETI, Ajiroghene S.
  • GOMETI, Ajiroghene S.
  • Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria.
  • Google Scholar
OGUGUA, Victor N.
  • OGUGUA, Victor N.
  • Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria.
  • Google Scholar
ODO, Christian E.
  • ODO, Christian E.
  • Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria.
  • Google Scholar
JOSHUA, Parker E.
  • JOSHUA, Parker E.
  • Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria.
  • Google Scholar


  •  Received: 21 October 2013
  •  Accepted: 29 January 2014
  •  Published: 05 February 2014

Abstract

The comparative effects of the chloroform extracts of the leaves of Psidium guajava (Myrtaceae), Anacardium occidentale (Anacardiaceae) and Eucalyptus globulus (Myrtaceae) and fruits of Xylopia aethiopica (Annonaceae) on blood glucose concentration and lipid levels of diabetic rats were investigated using standard methods. The results show 74, 82 and 83% reductions in the blood glucose concentrations upon the administration of A. occidentale (100 mg/kg body weight), E. globulus (100 mg/kg body weight) and X. aethiopica (250 mg/kg body weight) extracts respectively as from the 10th hour of treatments in relation to the 74 and 69% reductions in glibenclamide and diabetic untreated groups respectively while the synergic treatment group [A. occidentale + E. globulus (100 mg/kg body weight)] showed 83% decrease in the blood glucose concentration as from the 10th hour upon the administration of the combined extracts when compared with the values obtained for the glibenclamide and diabetic untreated groups. P. guajava extract had the greatest significant (p<0.05) reduction in the total cholesterol concentration of the treated rats. P. guajava + X. aethiopica treatment group in a similar manner showed the most significant (p<0.05) decrease in the triglyceride concentration of the treated rats. Hence, the individual performances of these extracts on blood glucose concentration and blood lipids confirm their ability to reduce blood glucose and diabetic complications.

 

Key words: Chloroform extract, Psidium guajava (Myrtaceae), Anacardium occidentale (Anacardiaceae), Eucalyptus globulus (Myrtaceae), Xylopia aethiopica (Annonaceae).