African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12227

Full Length Research Paper

Successful treatment of benign lesions by bis 3-azophenyl-4-hydroxy-6-methyl-pyran-2-one cobalt (II) in albino rats

Samina Shahid1, Shafiq ur Rehman2* and Ahmad Adnan2
1Institute of Chemistry, University of the Punjab, Lahore, Pakistan. 2Department of Chemistry, Government College University, Lahore-54000, Pakistan.
Email: [email protected]

  •  Accepted: 23 September 2010
  •  Published: 25 October 2010

Abstract

The study of the effect of bis 3-azophenyl-4-hydroxy-6-methyl-pyran-2-one cobalt (II) as chemotherapeutic agent was undertaken with the intention of studying the effects in 7,12-dimethylbenz[a] anthracene (DMBA) and tetradecanoyl phorbol-13-acetate (TPA) induced chemical carcinogenesis on skin of 5 - 7 weeks old healthy albino rats. The animals were divided into 5 groups (A, B, C, D and E) of twenty each. The rats were treated with carcinogens for 15 weeks and then the curative effect of bis 3-azophenyl-4-hydroxy-6-methyl-pyran-2-one cobalt (II) was observe. The bis 3-azophenyl-4-hydroxy-6-methyl-pyran-2-one cobalt (II) prevents malignant conversion of chemically induced benign tumors and did not kill cancer cells but change them to normal cells. It was concluded that if the complex is given in the pre-malignant phase of tumor development, it decreases the risk of malignant transformation.

 

Key words:    7,12-Dimethylbenz[a] anthracene (DMBA), tetradecanoyl phorbol-13-acetate (TPA), complex {bis-3-azophenyl-4-hydroxy-6-methyl-pyran-2-one cobalt (II)}, skin cancer.

Abbreviation

DMBA, 7,12 Dimethy1 benz(a) anthracence; TPA, 12-O-tetradecanoy-1-phorbol-13-acetate; DMF, dimethylformamide.