African Journal of

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12267

Full Length Research Paper

Effect of monosodium glutamate and aspartame on behavioral and biochemical parameters of male albino mice

Gasem Mohammad Abu-Taweel
  • Gasem Mohammad Abu-Taweel
  • Department of Basic Sciences, College of Education, Dammam University, P. O. Box 2375, Dammam-31451, Saudi Arabia.
  • Google Scholar

  •  Received: 30 December 2015
  •  Accepted: 29 March 2016
  •  Published: 13 April 2016


The present study aimed to investigate the individual and combined effect of mono-sodium glutamate (MSG) and aspartame (ASM) on biochemical, blood parameters and neuro-behavioral aspects of mice. The results indicated that exposure induced many changes in fear and anxiety behavior. The non-social and social behavior of the exposed mice was significantly affected, showing an increase in the former and a decrease in the later stages, respectively. The elements of social behavior including attack, numbers of fights and bites, naso-nasal and naso-genital contacts were decreased significantly. The latencies to threat and attack and first bite were increased significantly. Locomotor activity and neuromuscular coordination (grip strength) were decreased in treated animals as compared to the control group. There was a significant decrease in the red blood cell count, packed cell volume, hemoglobin concentration, white blood cell count platelets count and testosterone hormone in the treated males. The activity of acetylcholinesterase enzyme decreased as compared to the control. In conclusion, the current study indicated that exposure to food additives MSA and ASM was dangerous to mice in relation to behavior and biochemical analysis. In addition, these food additives need more scientific researches to investigate their effect on other parameters.

Key words: Mono-sodium glutamate, mono-sodium aspartame, fear and anxiety, locomotory behavior, grip strength, acetylcholinesterase.