African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12193

Review

Review of microfluidics approaches to mimic the kidney

Zach Odeh
  • Zach Odeh
  • Graduate School of Dalian Medical University, No. 9 Western Section Lvshun South Road, Lvshun 116044, China.
  • Google Scholar
Hongli Lin
  • Hongli Lin
  • Graduate School of Dalian Medical University, No. 9 Western Section Lvshun South Road, Lvshun 116044, China.
  • Google Scholar


  •  Received: 28 April 2019
  •  Accepted: 27 June 2019
  •  Published: 31 July 2019

Abstract

The use of microfluidics and nanotechnology in bioscience is gaining favor among the next generation of bioscience and clinical researchers, and this field has expanded to include organ-specific applications and modeling. While certain organ-specific microfluidic chips/applications, such as those in the heart and liver, are ubiquitous in the peer-reviewed literature, the kidneys require more focus and attention to drive innovation. This review is a comprehensive overview of kidney microfluidic bio-applications and includes the current challenges and limitations that should be the focus of research efforts. More specifically, previous research efforts focused on glomerular or tubule segments of the kidney, but never both anatomical regions. This is due, in part, to the complexity of reconstituting the kidney complete with all its variable mechanical and biochemical functions.

 

Key words: Kidney, organs and organ systems, microfluidics.