African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12198

Full Length Research Paper

Effect of magnetic iron oxide nanoparticles on pregnancy and testicular development of mice

Ali Noori1*, Kazem Parivar1, Mehrdad Modaresi2, Manoochehr Messripour2,Mohamad Hasan Yousefi3 and Gholam Reza Amiri4
  1Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran. 2Department of Physiology, Islamic Azad University-Khorasgan Branch, Isfahan, Iran. 3Department of physics and electro-optical engineering, Malek Ashtar University of Technology, Shahin Shahr, Iran. 4Falavarjan Branch, Islamic Azad University, Isfahan, Iran
Email: [email protected]

  •  Accepted: 23 December 2010
  •  Published: 14 February 2011

Abstract

 

In this study, considering the high sensitivity of developing fetal organs, different doses of iron oxide nanoparticles coated with dimercaptosuccinic acid (DMSA) were injected intraperitoneally to pregnant mice. The magnetic and structural properties of DMSA-coated nanoparticles were examined by Alternating Gradient-Force Magnetometry, X-Ray Diffraction and Fourier Transform Infrared Spectroscopy. The histological studies of the fetal liver and placenta sections showed presence of nanoparticles in these organ systems. Weight change and the number of pups born by pregnant mice in comparison with controls were not significantly different. But, a significant decrease was seen in infants growth from the mothers treated with doses higher than 50 mg/kg. The testicular histological studies of these infants showed decrease in spermatogonia, spermatocytes, spermatids and mature sperm significantly. Although, some studies revealed the nontoxic effect of iron oxide nanoparticles in adult mice, the present study indicated that, the doses higher than 50 mg/kg of DMSA-coated magnetic nanoparticles can disrupt embryo development.

 

Key words: Magnetic nanoparticles, pregnancy, testicular development, toxicity.

Abbreviation

DMSA, dimercaptosuccinic acid; XRD, X-ray diffraction; FTIR, fourier transform infrared spectroscopy; AGFM, alternating gradient force magnetometry.

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