African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12514

Full Length Research Paper

Studies on anti-ulcer, analgesic and antipyretic properties of the ethanolic leaf extract of Gongronema latifolium in rodents

Akuodor G. C.1*, Idris-Usman M. S.1, Mbah, C. C.2, Megwas U. A.3, Akpan, J. L.4, Ugwu T. C.5, Okoroafor D. O.6 and Osunkwo U. A.1
1Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development (NIPRD), P. M. B. 21, Garki, Abuja, Nigeria. 2Department of Pharmaceutical Technology and Raw Materials Development, National Institute for Pharmaceutical Research and Development (NIPRD), P. M. B. 21, Garki, Abuja, Nigeria. 3Department of Pharmacology and Therapeutics, Abia State University, Uturu, Nigeria. 4Department of Pharmacology and Therapeutics, Faculty of Clinical Medicine, Ebonyi State University, Abakaliki, Nigeria. 5Department of Pharmacology and Clinical Pharmacy. Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Nigeria. 6Department of Pharmacology and Therapeutics. Nnamdi Azikiwe University, Awka, Nigeria.  
Email: [email protected]

  •  Accepted: 11 January 2010
  •  Published: 30 April 2010

Abstract

The ethanol extract of Gongronema latifolium leaves were evaluated for anti-ulcer, analgesic and anti pyretic activities in rats and mice. Ethanol-induced gastric ulceration, acetic acid-induced writhing and formalin-induced nociception were used. Yeast-induced hyperpyrexia was used to investigate the antipyretic activity. The extract produced a significant ulcer protective activity in rats. The extract also decreased pain induced both by acetic acid in mice and early phase of formalin test in rats. A significant reduction in hyperpyrexia was also produced by the extract in rats. This present study provides a strong evidence of anti-ulcer, analgesic and antipyretic activities of G. latifolium.

 

Key words: Gongronema latifolium, analgesic, antipyretic, ulcer-protective

Abbreviation

IP, Intraperitoneally; ASA, acetylsalicylic acid; SC, subcutaneously;COX-2, cyclooxygenase- 2; PG, prostaglandin; PGE2, prostaglandin E2; LD50, half maximum lethal dose; SEM, standard error of mean.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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