African Journal of

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12392

Full Length Research Paper

Antiviral activity of Aloe vera against herpes simplex virus type 2: An in vitro study

  Keivan Zandi¹*, Moloud Abbas Zadeh¹, Kohzad Sartavi² and Zahra Rastian¹  
  1Persian Gulf Health Research Centre, Bushehr University of Medical Sciences, Bushehr, Iran. 2Jahad Keshavarzi Research Centre, Bushehr, Iran.
Email: [email protected] or [email protected]

  •  Accepted: 26 June 2007
  •  Published: 31 August 2007



In this study we tested the antiviral activity of a crude hot glycerine extract of Aloe veragel which was grown in Bushehr (Southwest of Iran) against HSV-2 replication in Vero cell line. The extract showed antiviral activity against HSV-2 not only before attachment and entry of virus to the Vero cells but also on post attachment stages of virus replication. The IC50 before attachment and entry of virus to the cells is 428 µg/ml and the CC50 value which is the cytotoxicity of the extract for Vero cells is 3238 µg/ml, while the calculated selectivity index (SI) is 7.56. Also, IC50 of extract on post attachment stages of replication is 536 µg/ml and the SI value for inhibition of the post attachment stages of HSV-2 replication is 6.04. Therefore, compounds of Aloe verafrom Bushehr could be a good candidate as a natural source for antiviral drug development against HSV-2.


Key words: Aloe vera, antiviral, HSV-2, hot glycerine extract.