African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12083

Full Length Research Paper

Resveratrol inhibits cell viability and proliferation via apoptotic pathways in ovarian cancer

YAO Jing-ping
  • YAO Jing-ping
  • Department of Gynecological Oncology, Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research & Nanjing Medical University Affiliated Cancer Hospital, Nanjing 210000, China.
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XU Fei
  • XU Fei
  • Nanjing Maternity and Child Health Care Hospital, the Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University, Nanjing 210000, China.
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LI Rong
  • LI Rong
  • Nanjing Maternity and Child Health Care Hospital, the Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University, Nanjing 210000, China.
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LI Meng
  • LI Meng
  • JianAn Medical Technology Ltd., Nanjing 21000, China.
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QU Jun-wei
  • QU Jun-wei
  • Department of Gynecological Oncology, Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research & Nanjing Medical University Affiliated Cancer Hospital, Nanjing 210000, China.
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  •  Received: 26 July 2018
  •  Accepted: 25 September 2018
  •  Published: 03 October 2018

Abstract

Ovarian cancer is the most common female malignancy and the main cause of death from gynecological malignancies. Resveratrol (3,4,5 tri-hydroxystilbene) is a phytoalexin and a polyphenolic compound present in human dietary material such as peanuts, mulberries, grapes and red wine. We demonstrated that resveratrol depressed the proliferation of HO8910PM cells in a dose-dependent and time-dependent manner in vitro (P < 0.001). Resveratrol not only decreased ovarian tumor volume and weight but also influence the tumor forming time in vivo (P < 0.001). The cell cycle S phase was arrested in response to resveratrol treatment. Caspases activity were also detected by western-blotting in HO8910PM cells treated with resveratrol. Caspase-3 or/and caspase-9 were highly activated in resveratrol-treated HO8910PM cells or xerngraft model (P < 0.001). Resveratrol significantly inhibits growth and induces apoptosis in HO8910PM cells both in vitro and in vivo, suggesting that resveratrol is a potential treatment or supplementary measure of ovarian carcinoma.

 

Key words: Resveratrol, ovarian cancer, apoptosis, cytochrome C, caspase.