African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12487

Full Length Research Paper

The effect of CoQ10 and vitamin E on serum total sialic acid, lipid-bound sialic acid, some trace elements and minerals in rats induced with doxorubicin

Gökhan Oto1*, Suat Ekin2, Semih YaÅŸar3, Hülya Özdemir1 and Fatmagül Yur4      
1Department of Pharmacology, Medical Faculty, Yuzuncu Yil University, Van, Turkey. 2Department of Biochemistry, Faculty of Arts and Sciences, Yuzuncu Yil University, Van, Turkey. 3Department of Biochemistry, Faculty of Arts and Sciences, Bingöl University, Bingöl, Turkey. 4Department of Biochemistry, Faculty of Veterinary, Yuzuncu Yil University, Van, Turkey.  
Email: [email protected]

  •  Accepted: 28 April 2011
  •  Published: 13 June 2011

Abstract

This study was designed to evaluate the effect of CoQ10 and vitamin E on serum total sialic acid (TSA), lipid bound sialic acid (LSA) and some elements in rat administered doxorubicin (DXR). Cu levels were increased in the group treated with DXR + vitamin E in comparison with DXR (p<0.05) and CoQ10 groups (p = 0.001). Furthermore, copper levels were increased in the group treated with DXR + CoQ10 in comparison with CoQ10 group (p < 0.05). Zn levels were decreased in the group treated with DXR + vitamin E in comparison with CoQ10 group (p < 0.05). Mg levels were decreased in subjects treated with DXR + vitamin E in comparison with the control group values (p < 0.05). Particularly, the observed increase in Cu levels in rats from DXR + vitamin E group might be due to the decrease of vitamin E. However, the oxidative damage could be as a result of DXR occurence and may be helpful to clinicians in chemotherapy using anthracycline.

 

Key words: Doxorubicin, total sialic acid (TSA), lipid bound sialic acid (LSA), trace elements, minerals.