African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12267

Full Length Research Paper

In vitro trypanocidal effect of methanolic extract of some Nigerian savannah plants

S.E. Atawodi1*, T. Bulus1, S. Ibrahim1, D.A. Ameh1, A.J. Nok1, M. Mamman2, M. Galadima3
  1Biochemistry Department, Ahmadu Bello University, Zaria, Nigeria. 2Veterinary Physiology and Pharmacology Department, Ahmadu Bello University, Zaria, Nigeria. 3Microbiology Department, Ahmadu Bello University, Zaria, Nigeria.
Email: [email protected]

  •  Accepted: 10 August 2003
  •  Published: 30 September 2003

Abstract

 

Methanol extracts from twenty three plants harvested from the Savannah vegetation belt of Nigeria were analyzed in vitro for trypanocidal activity against Trypanosoma brucei brucei and Trypanosoma congolense at concentrations of 4 mg/ml, 0.4 mg/ml and 0.04 mg/ml. Extracts of Khaya senegalensis, Piliostigma reticulatum, Securidacalongepedunculata and Terminalia avicennoides were strongly trypanocidal to both organisms while extracts of Anchomanes difformis, Cassytha spp, Lannea kerstingii, Parkia clappertioniana, Striga spp, Adansonia digitata and Prosopis africana were trypanocidal to either T. brucei brucei or T. congolense. These findings provide evidence of the effects of some plants in the traditional management of trypanosomiasis.

 

Key words: Savannah, medicinal plants, trypanocidal effects, trypanosomiasis, trypanosome, in vitro model.