African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12405

Full Length Research Paper

In vitro anti-hyperglycaemic effect of glucocapparin isolated from the seeds of Boscia senegalensis (Pers.) Lam. ex Poiret

  Mahamat Nour Adam Sakine1, Yaya MAHMOUT1*, M. G. Dijoux-Franca2, Joachim Gbenou3 and Mansourou Moudachirou3      
  1Laboratoire de Recherche sur les Substances Naturelles, Faculté des Sciences Exactes et Appliquées, Université de N’djamena, Tchad. 2Département de Botanique, Pharmacognosie et Phytothérapie, UMR CNRS Ecologie Microbienne. Institut des Sciences Pharmaceutiques et Biologique – Faculté de Pharmacie, Université Claude Bernard – Lyon 1, France. 3Laboratoire de Pharmacognosie et des Huiles Essentielles (LAPHE) Université d’Abomey-Calavi, Benin.
Email: [email protected]

  •  Accepted: 14 February 2012
  •  Published: 20 March 2012

Abstract

 

Glucocapparin (I) used in this study was isolated from the seeds of Bosciasenegalensis (family Capparidaceae). The structure of (I) was determined on the basis of an extensive analysis of the spectroscopic data. Brine shrimp lethality bioassay of (I) showed a marked significant cytotoxic activity with LC50 = 16.482 μg/ml. Compound (I) reduced the liberation of glucose from the liver of rabbits. The active concentration was 30 mg/ml showing that the in vitro anti-hyperglycaemic effect shown could be related to the traditional use of B. senegalensis seeds in Chad against type 2 diabetes.

 

Key words: Boscia senegalensis, glucocapparin, liver glucose inhibition, cytotoxicity.