The aim of the study was to evaluate the effect of Sage officinalis leaf extract in tramadol-induced rats. Standard methods of analysis were used for the study. Fifty rats were divided into Group A (Control) - feed and water only. Group B -induced with tramadol at 50mg/kg body weight, Group C -induced with tramadol + 150mg/kg of SOL extract, Group D -tramadol + 300mg/kg SOL extract, Group E -tramadol + 400mg/kg SOL extract. The results showed high concentrations of phytochemical and trace elements at various concentrations. There were increases in Aspartate amino transaminase, Alanine aminotransferase, Gamma gluamyltransferase, Alkaline phosphatase and increase in Total protein, albumin, total bilirubin, conjugated bilirubin, sodium, potassium, chloride, bicarbonate, urea, calcium, creatinine, total cholesterol, magnesium, hemoglobin, Packed cell volume, Total white blood cell count at a significant difference (p ? 0.05) in Group B when compared with Group A. However, in Groups C,D and E there was statistical significant decrease (p ? 0.05) in Aspartate amino transaminase, Alanine aminotransferase, Gamma gluamyltransferase, alkaline phosphatase and total protein, albumin, total bilirubin, conjugated bilirubin, sodium, potassium, chloride, bicarbonate, urea, calcium, creatinine, total cholesterol and magnesium compared with the Group B. The study portends that Sage officinalis leaf could be of an unalloyed health benefits in the management of tramadol-induced toxicity in rats.

Keywords: Tramadol, Sage, Phytochemicals/Elements, Markers, Rats