African Journal of

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12269

Full Length Research Paper

Extraction and physicochemical characterization of a potential multifunctional pharma-excipient from crab shell wastes

Emmanuel O. Olorunsola, Olubunmi J. Olayemi, Stephen O. Majekodunmi and Unyime B. Etukudo
1Department of Pharmaceutics and Pharmaceutical Technology, University of Uyo, Uyo, Nigeria. 2Department of Pharmaceutics and Pharmaceutical Microbiology, Ahmadu Bello University, Zaria, Nigeria.
Email: [email protected]

  •  Received: 14 June 2015
  •  Accepted: 30 September 2015
  •  Published: 07 October 2015


Aulton ME (2007). Properties of solutions. In: Aulton ME (ed). The Design and Manufacture of Medicine. Churchill Livingstone, Elsevier, pp. 33 - 41.
Beristain C, Perez-Alonso CI, Lobato-Calleros C, Rodriguez-Huezo ME, Vernon-Carter EJ (2006). Thermodynamic analysis of the sorption isotherms of pure and blended carbohydrate polymers. J. Food Eng. 77:753-760.
Builders PF, Chukwu C, Obidike I, Builders MI, Attama AA, Adikwu MU (2009). A novel xyloglucan gum from seeds of Afzelia africana Se. Pers.: Some functional and Physicochemical properties. Int. J. Green Pharm. 3(2):112-118.
Burrow F, Louime C, Abazinge M, Onokpise O (2007). Extraction and evaluation of chitosan from crab exoskeleton as a seed fungicide and plant growth enhancer. Am. Eurasian J. Agric. Environ. Sci. 2(2): 103-111.
Chiappisi L, Gradzielski M (2015). Co-assembly in chitosan-surfactant mixtures: Thermodynamics, structures, interfacial properties and applications. Adv. Colloid Interface Sci. 220:92-107.
Chung H, Lee E, Lim S (2002). Comparison in glass transition and enthalpy relaxation between native and gelatinized rice starches. Carbohydr. Polym. 48:287-298.
Coutts RT (2008). Infrared Spectroscopy. In: Chatten LG (ed). Pharmaceutical Chemistry – Instrumental Techniques. CBS Publishers and Distributors PVT Ltd., New Delhi, India, pp. 59 – 125.
Horvat M, Mestrovic E, Danilovski A, Craig DMQ (2005). An investigation into the thermal behavior of a model drug mixture with amorphous trehalose. Int. J. Pharm. 294:1- 10.
Hu L, Sun Y, Wu Y (2013). Advances in chitosan-based drug delivery vehicles. Nanoscale 5: 3103-3111.
Iqbal MS, Massey S, Akbar J, Ashraf CM (2013). Thermal analysis of some natural polysaccharides by isoconversional method. Food Chem. 140(1-2):178-182.
Kepsutlu AR, Savaser A, Ozkan Y, Dikmen N, Isimer A (1999). Evaluation of chitosan used as an excipient in tablet formulations. Acta Pol. Pharm. 36(3):227-235.
Kos MK, Boqataj M, Mrhar A (2008). Heparin decreases permeability of pig urinary bladder wall preliminarily enhanced by chitosan. Drug Deliv. Ind. Pharm. 34(2):215-220.
Olorunsola EO, Bhatia PG, Tytler BA, Adikwu MU (2014). Some chemical characteristics of novel hemicellusic gums from seeds of Afzelia africana and Prosopis africana. West Afr. J. Pharm. 25: 31-40.
Sonia TA, Sharma CP (2011). Chitosan and its derivatives for drug delivery. Adv. Polym. Sci. 243:23 – 54.
Tian F, Sandler N, Gordon KC, McGoverin CM, Reay A, Strachan CJ, Saville DJ, Rades T (2006). Visualizing the conversion of carbamazepine in aqueous suspensions with and without presence of excipients: a single crystal study using SEM and Raman microscopy. Eur. J. Pharm. Biopharm. 64(3):326 -335.
USEPA (2014). Waste management options. United State Environmental Protection Agency. Available at (cited on June 14, 2015).
Wang QZ, Chen XG, Liu N, Wang SX, Liu CS, Meng XH, Liu CG (2006). Protonation constant of chitosan with different molecular weight and degree of deacetylation. Carbohydr. Polym. 65:194-201.
Wells SJ, Aulton ME (2007). Pharmaceutical preformulation. In: Aulton ME (ed). The Design and Manufacture of Medicine. Churchill Livingstone, Elsevier, pp. 336-360.
Yin L, Ding J, He C, Cui L, Tang C, Yin C (2009). Drug permeability and mucoadhesive properties of thiolated chitosan nanoparticles in oral insulin delivery. Biomaterial 30:5691-5700.