African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12191

Review

Food additives and their health effects: A review on preservative sodium benzoate

Bruna G. O. Linke
  • Bruna G. O. Linke
  • Industrial Biotechnology Program, Universidade Positivo, Prof. Pedro Viriato Parigot de Souza Street, 5300, Campo Comprido, Curitiba, Paraná, Brazil.
  • Google Scholar
Thais A. C. Casagrande
  • Thais A. C. Casagrande
  • Industrial Biotechnology Program, Universidade Positivo, Prof. Pedro Viriato Parigot de Souza Street, 5300, Campo Comprido, Curitiba, Paraná, Brazil.
  • Google Scholar
Lígia A. C. Cardoso
  • Lígia A. C. Cardoso
  • Industrial Biotechnology Program, Universidade Positivo, Prof. Pedro Viriato Parigot de Souza Street, 5300, Campo Comprido, Curitiba, Paraná, Brazil.
  • Google Scholar


  •  Received: 02 September 2017
  •  Accepted: 09 February 2018
  •  Published: 07 March 2018

References

Abu-Taweel GM (2016). Effect of monosodium glutamate and aspartame on behavioral and biochemical parameters of male albino mice. Afr. J. Biotechnol. 15(15):601-612.
Crossref

 

Akintonwa A, Awodele O, Emeka PM, Osajare O (2007). The mutagenic potentials of potassium bromate and some commonly used food additives. Afr. J. Biotechnol. 6(8):1004-1006.

 
 

Antunes SC, Nunes B, Rodrigues S, Nunes R, Fernandes J, Correia AT (2016). Effects of chronic exposure to benzalkonium chloride in Oncorhynchus mykiss: cholinergic neurotoxicity, oxidative stress, peroxidative damage and genotoxicity. Environ. Toxicol. Pharmacol. 45:115-122.
Crossref

 
 

Aun MV, Mafra C, Phillipi JC, Kalil J, Agondi RC, Motta AA (2011). Food Additives. Rev. Bras. Alerg. Imunopatol. 34(5):177-186.

 
 

Beezhold BL, Johnston CS, Nochta KA (2014). Sodium benzoate-rich beverage consumption is associated with increased reporting of ADHD symptoms in college students: A pilot investigation. J. Atten. Disord. 18(3): 236-241.
Crossref

 
 

Boris M, Mandel FS (1994). Foods and additives are common causes of attention deficit hyperactivity disorder in children. Ann. Allergy. 72(5):462-468.

 
 

Bridges JW, French MR, Smith RL, Willians RT (1970). The fate of benzoic acid in various species. Biochem. J. 118(1):47-51.
Crossref

 
 

Cardoso LAC, Karp SG, Vendruscolo F, Kanno KYF, Zoz LIC, Carvalho JC (2017a). Biotechnological Production of Carotenoids and Their Applications in Food and Pharmaceutical Products, Carotenoids, Prof. Dragan Cvetkovic (Ed.), InTech, Available at: 

View

 
 

Cardoso LAC, Kanno KYF, Karp SG (2017b). Microbial production of carotenoids–A review. Afr. J. Biotechnol. 16(4):139-146.
Crossref

 
 

Carocho M, Morales P, Ferreira ICFR (2015). Natural food additives:Quo vadis? Trends Food Sci. Technol. 45(2):284-295.
Crossref

 
 

Codex Alimentarius (2017). Food additives. Available at: 

View

 
 

Di Sotto A, Maffei F, Hrelia P, Di Giacomo S, Pagano E, Borrelli F, Mazzanti G (2014). Genotoxicity assessment of some cosmetic and food additives. Regul Toxicol Pharmacol. 68:16-22.
Crossref

 
 

European food Safety Authority (EFSA) Regulation (2017). Regulation nº1333/2008. Available at: 

View

 
 

Emerton V, Choi E (2008). Essential guide to food additives, 3 ed., Surrey, UK: Leatherhead Publishing.

 
 

Food and Drug Administration of the United States of America (FDA)(2017). Food and beverages. Available at: 

View

 
 

Gören C, Bilsel G, Simsek A, Bilsel M, Akcadaq F, Topal K, Ozqen H (2015). HPLC and LC–MS/MS methods for determination of sodium benzoate and potassium sorbate in food and beverages: Performances of local accredited laboratories via proficiency tests in Turkey. Food Chem. 175:273-279.
Crossref

 
 

Hill HJ (1993). Food additives and contaminants and their contribution to the human cancer load. Eur. J. Cancer Prev. 2(4):291-292.
Crossref

 
 

Honorato TC, Batista E, Nascimento KO, Pires T (2013). Food additives: applications and toxicology. Rev. Verde Agroec. Desenv. Sustáv. 8(5):01-11.

 
 

Lennerz BS, Vafai SB, Delaney NF, Clish AB, Deik AA, Pierce KA, Ludwig DS, Mootha VK (2015). Effect of sodium benzoate, a widely used food preservative, on glucose homeostasis and metabolic profiles in humans. Mol. Genet. Metab. 114(1):73-79.
Crossref

 
 

Loco JV, Vandevijvere S, Cimencio O, Vinkx C, Goscinny S (2015). Dietary exposure of the Belgian adult population to 70 food additives with numerical ADI. Food Control 54:86-94.
Crossref

 
 

Martyn, DM, Mcnulty, BA, Nugget, AP, Gibney MJ (2013). Food additives and preschool children. Proc. Nutr. Soc. 72(1):109-116.
Crossref

 
 

McCann D, Barrett A, Cooper A, Crumpler D, Dalen L, Grimshaw K, Kitchin E, Lok K, Porteous L, Prince E, Sonuga-Barke E, Warner JO, Stevenson J (2007). Food additives and hyperactive behaviour in 3-year-old and 8/9-year-old in the community: a randomised, Double-blinded, placebo-controlled Trial. Lancet. 370(9598):1560-1567.
Crossref

 
 

Mellado-García P, Maisanaba S, Puerto M, Prieto AI, Marcos R, Pichardo S, Camean AM. In vitro toxicological assessment of an organosulfur compound from Allium extract: Cytotoxicity, mutagenicity and genotoxicity studies. Food Chem. Toxicol. 99:231-240.
Crossref

 
 

Michaelsson G, Juhlin L (1973). Urticarial induced by preservatives and dye additives in foods and drugs. Br. J. Dematol. 88(6):525-532.
Crossref

 
 

Mpountoukas P, Vantarakis A, Sivridis E, Liliaris T (2008). Cytogenetic study in cultured human lymphocytes treated with three. Food Chem. Toxicol. 46(7):2390-2393.
Crossref

 
 

Nair B (2001). Final report on the safety assessment of benzyl alcohol, benzoic acid, and sodium benzoate. Int. J. Toxicol. 20(3):23-50.

 
 

Noorafshan A, Erfanizadeh M, Doust SK (2014). Stereological studies of the effects of sodium benzoate or ascorbic acid on rats' cerebellum. Saudi Med. J. 35(12):1494-1500.

 
 

Polônio MLT, Peres F (2009). Food additive intake and health effects: public health challenges in Brazil. Cad. Saúde Pública 25(8):1653-1666.
Crossref

 
 

Pongsavee M (2015). Effect of sodium benzoate preservative on micronucleus induction, chomosome break, and Ala40Thr superoxide dismutase gene mutation in lymphocytes, Biomed. Res. Int. 2015:1-5.
Crossref

 
 

Ramalho VC, Jorge N (2006). Antioxidants used in oils, fats and fatty foods. Quím. Nova. 29(4):755-760.

 
 

Ren L, Meng M, Wang P, Xu Z, Eremin SA, Zhao J, Yin Y, Xi R (2014). Determination of sodium benzoate in food products by fluorescence polarization immunoassay. Talanta 121:136-143.
Crossref

 
 

Tfouni AS, Toledo MC (2002). Estimates of the mean per capita daily intake of benzoic and sorbic acids in Brazil. Food Addit. Contam. 19(7):647-654.
Crossref

 
 

Thomas OE, Adegoke OA (2015). Toxicity of food colours and additives: A review. Afr. J. Biotechnol. 9(36):900-914.

 
 

Toledo MCF, Tfouni SAV (2002). Determination of benzoic and sorbic acids in Brazilian food. Food Contl. 13(2):117-123.
Crossref

 
 

Tsay HJ, Wang YH, Chen WL, Huang MY, Chen YH (2007). Treatment with sodium benzoate leads to malformation of zebrafish larvae. Neurotoxicol. Teratol. 29(5):562-569.
Crossref

 
 

Turkoglu S (2007). Genotoxicity of five preservatives tested on root tips of Allium cepa L. Mutat. Res. 626(1-2):4-14.
Crossref

 
 

Varela P, Fiszman SM (2013). Exploring consumer's knowledge and perceptions of hydrocolloids used as food additives and ingredients. Food Hydrocoll. 30(1):477-484.
Crossref

 
 

World Health Organization (WHO) (2017). Principles for the Safety Assessment of Food Additives and Contaminants in Food, 1987 Available at: 

View

 
 

Yavav A, Kumar A, Das M, Tripathi A (2016). Sodium benzoate, a food preservative, affects the functional and activation status of splenocytes at non cytotoxic dose. Food Chem. Toxicol. 88:40-47.
Crossref

 
 

Zengin N, Yüzbasıoglu D, Ünal F, Yilmaz S, Aksoy H (2011). The evaluation of the genotoxicity of two food preservatives: Sodium benzoate and potassium benzoate. Food Chem. Toxicol. 49(4):763-769.
Crossref

 
 

Zhang G, Ma Y (2013). Spectroscopic studies on the interaction of sodium benzoate, a food preservative, with calf thymus DNA. Food Chem. 141(1):41-47.
Crossref