African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12271

Full Length Research Paper

Ex-vivo evaluation of crab shell chitosan as absorption enhancer in ciprofloxacin tablet formulation

Emmanuel O. Olorunsola
  • Emmanuel O. Olorunsola
  • Department of Pharmaceutics and Pharmaceutical Technology, University of Uyo, Uyo, Nigeria.
  • Google Scholar
Timma O. Uwah
  • Timma O. Uwah
  • Department of Pharmaceutics and Pharmaceutical Technology, University of Uyo, Uyo, Nigeria.
  • Google Scholar
Olubunmi J. Olayemi
  • Olubunmi J. Olayemi
  • Department of Pharmaceutical Technology and Raw Material Development, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria.
  • Google Scholar
Unyime B. Etukudo
  • Unyime B. Etukudo
  • Department of Pharmaceutics and Pharmaceutical Technology, University of Uyo, Uyo, Nigeria.
  • Google Scholar


  •  Received: 03 May 2016
  •  Accepted: 24 August 2016
  •  Published: 07 September 2016

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Ashford M (2007). Introduction to biopharmaceutics. In: Aulton ME (ed). The Design and Manufacture of Medicine. Churchill Livingstone, Elsevier. pp. 266-269.

 
 

Campoli-Richard DM, Monk JP, Price A, Benfield P, Todd PA, Ward L (1998). Ciprofloxacin: A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs 35:373-447.
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Olorunsola EO, Olayemi OJ, Majekodunmi SO, Etukudo UB (2015). Extraction and physicochemical characterization of a potential multifunctional pharma-excipient from crab shell wastes. Afr. J. Biotechnol. 14(40):2856-2861.
Crossref

 
 

Ritthidej GC, Chomto P, Pummangura S, Menasveta P (1994). Chitin and chitosan as disintegrants in paracetamol tablets. Drug Dev. Ind. Pharm. 20(13):2109-2134.
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Sharma N, Kulkarni GT, Sharma A (2013). Development of novel Abelmoschus esculentus (Okra) gel for nasal delivery of rizatriptan benzoate. Trop. J. Pharm. Res. 12(2):149-153.

 
 

Sonia TA, Sharma CP (2011). Chitosan and its derivatives for drug delivery. Adv. Polym. Sci. 243:23-54.
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Uhumwangho MU, Okor RS, Eichie FE, Abbah CM (2006). Influences of some starches on the brittle fracture tendency of paracetamol tablets. Afr. J. Biotechnol. 5(20):1950-1953.

 
 

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Wu CY, Benet L (2005). Predicting drug disposition via application of BCS: transport / absorption / elimination interplay and development of a biopharmaceutics drug disposition classification system. Pharm. Res. 22:11-23.
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Yin L, Ding J, He C, Cui L, Tang C, Yin C (2009). Drug permeability and mucoadhesive properties of thiolated chitosan nanoparticles in oral insulin delivery. Biomaterial 30:5691-5700.
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