African Journal of
Biochemistry Research

  • Abbreviation: Afr. J. Biochem. Res.
  • Language: English
  • ISSN: 1996-0778
  • DOI: 10.5897/AJBR
  • Start Year: 2007
  • Published Articles: 403

Article in Press

BLOOD STABILITY PARAMETERS AS INDICES OF HEMATOLOGICAL DISORDERS REMAIN PRESERVED ON EXPOSURE TO CORCHORUS OLITORUS LEAF CONSUMPTION

OMEJE KINGSLEY OZIOMA

  •  Received: 22 May 2018
  •  Accepted: 06 July 2018
This study focused on the integrity retention profile of hematological disorder indices on exposure to ethanol extract of Corchorus olitorus leaf. Seventy two apparently healthy rats were obtained from the animal farm of the Department of Zoology and Environmental Biology University of Nigeria, Nsukka and used for this study. These indices include assessed were Red blood cell distribution width standard deviation, Red blood cell distribution width coefficient of variation, Platelet Distribution Width, Mean Platelet Volume and Platelet Large Cell Ratio after oral administration of 50, 100 and 200 mg/kg body weight of the extract to three groups of rat for 30, 90 and 180 days. These indices were analyzed using automated Hematology Sysmex analyzer. The results showed a non-significant changes in the indices which include red blood cell distribution width standard deviation, red blood cell distribution width coefficient of variation, platelet distribution width, and mean platelet volume for groups respectively. The results of this study revealed that oral administration of C. olitorus could not cause significant increase of the platelet indices at the doses studied. Suggesting that C. olitorus leaf does not put the system at risk of any blood associated disorder or disease.

Keywords: Blood Stability, Hematological disorders, Corchorus olitorus, leaf, wistar rat