African Journal of
Biochemistry Research

  • Abbreviation: Afr. J. Biochem. Res.
  • Language: English
  • ISSN: 1996-0778
  • DOI: 10.5897/AJBR
  • Start Year: 2007
  • Published Articles: 413

Full Length Research Paper

Evaluation of acute oral toxicity, hemato-biochemical activity and physiological responses of rabbits and rats administered Moringa oleifera leaf extract and meal

Basile Boni Saka Konmy
  • Basile Boni Saka Konmy
  • Zootechnical Research and Livestock System Unit, Laboratory of Animal and Fisheries Science (LaSAH), National University of Agriculture, 01 BP: 55PORTO-NOVO, Benin.
  • Google Scholar
Pascal Abiodoun Olounladé
  • Pascal Abiodoun Olounladé
  • Zootechnical Research and Livestock System Unit, Laboratory of Animal and Fisheries Science (LaSAH), National University of Agriculture, 01 BP: 55PORTO-NOVO, Benin.
  • Google Scholar
Sanni-yo Doko-Allou
  • Sanni-yo Doko-Allou
  • Zootechnical Research and Livestock System Unit, Laboratory of Animal and Fisheries Science (LaSAH), National University of Agriculture, 01 BP: 55PORTO-NOVO, Benin.
  • Google Scholar

  •  Received: 16 January 2020
  •  Accepted: 14 October 2020
  •  Published: 31 October 2020


Aboh A, Olaafa M, Dossou-Gbété G, Dossa A, Djagoun N (2002). Ingestion volontaire et digestibilité apparente d'une ration à base de la farine de graines de Mucuna pruriens var. utilis complétée de fourrages chez les lapins. Tropicultura 20(4):165-169.


Ahamefule F, Obua B, Ukweni I, Oguike M, Amaka R (2008). Haematological and biochemical profile of weaner rabbits fed raw or processed pigeon pea seed meal based diets. African Journal of Agricultural Research 3(4):315-319.


Ahemen T, Abu AH, Iorgilim LK (2013). Physiological responses of rabbits fed graded levels of Moringa oleifera leaf meal (MOLM): Some aspects of haematology and serum biochemistry. Archives of Applied Science Research 5(2):172-176.


Akouango P, Opoye I, Ngokaka C, Akouango F (2014). Contribution à la réduction des périodes improductives du cycle de reproduction des lapines (Oryctolagus cuniculus) dans un élev age fermier. Afrique Science: Revue Internationale des Sciences et Technologie 10(2): 356-364.


Bitto I, Arubi J, Gumel A (2006). Reproductive tract morphometry and some haematological characteristics of female rabbits fed pawpaw peel meal based diets. African Journal of Biomedical Research 9(3).


Burns KF, De Lannoy CW (1966). Compendium of normal blood values of laboratory animals, with indication of variations: I. Random-sexed populations of small animals. Toxicology and Applied Pharmacology 8(3):429-437.


Campbell T (2015). Exotic animal hematology and cytology: John Wiley & Sons, Inc. 402 p. 


Church JP, Judd JT, Young CW, Kelsay JL, Kim WW (1984). Relationships among dietary constituents and specific serum clinical components of subjects eating self-selected diets. The American Journal of Clinical Nutrition 40(6):1338-1344.


Combes S (2004). Valeur nutritionnelle de la viande de lapin. INRAE Productions Animales 17(5):373-383.


Dougnon V, Bankolé H, Edorh P, Klotoé JR, Dougnon J, Fah L, Loko F, Boko M (2013). Acute toxicity of Solanum macrocarpon Linn (Solanaceae) on Wistar rats: study about leaves and fruits. American Journal of Biochemistry 3:84-88.


Duncan D (1955). Multiple range and multiple F tests. Biometrics 11(1):1-42.


Duncan GJ, Brooks‐Gunn J, Klebanov PK (1994). Economic deprivation and early childhood development. Child Development 65(2):296-318.


Ewuola E, Egbunike G (2008). Haematological and serum biochemical response of growing rabbit bucks fed dietary fumonisin B1. African Journal of Biotechnology 7(23):4304-4309.


Ewuola E, Jimoh O, Atuma O, Soipe O (2012). Haematological and serum biochemical response of growing rabbits fed graded levels of Moringa oleifera leaf meal. World Rabbit Science Association Proceedings 3(6):683-679.


Iheukwuemere F, Abu A, Ameh M (2006). Effect of human menopausal gonadotropin on haematological and serum biochemical parameters of the Nigerian Indigenous chickens. International Journal of poultry Science 5(7):632-634.


Jain N (1983). Scanning electron micrograph of blood cells. Schalm's Veterinary Haematology 4:63-70.


Jiwuba P, Ikwunze K, Dauda E, Ugwu D (2016). Haematological and serum biochemical indices of growing rabbits fed diets containing varying levels of Moringa oleifera leaf meal. British Biotechnology Journal 15(2):1-7.


Jonathan AE, Etuk EU, Bello SO, Gwarzo MS, Egua MO, Nkwoka IJ (2014). In vitro Antibacterial Activities of Aqueous and Ethanolic Stem Bark Extracts of Bridelia ferruginea Benth. International Journal of Current Research in Biosciences and Plant Biology 1(5):28-31.


Kpodekon M, Toleba S, Boko C, Dagnibo M, Djago Y, Dossa F, Farougou S (2015). Fréquence des Escherichia coli entéropathogènes chez les lapins (Oryctolagus cuniculus) dans la commune d'Abomey-Calavi en zone sub-équatoriale du Bénin. Revue de Médecine Vétérinaire 166(3-4):84-89.


Lenarczyk M, Lam V, Jensen E, Fish B, Su J, Koprowski S, Komorowski R, Harmann L, Migrino R, Li X, Hopewell J, Moulder J, Baker J (2013). Cardiac Injury after 10 Gy Total Body Irradiation: Indirect Role of Effects on Abdominal Organs. Radiation Research 180(3):247.


Mitruka BM, Rawnsley HM (1977). Clinical biochemical and hematological reference values in normal experimental animals: Masson Pub. USA pp. 1981-413.


Oduola T, Adeniyi F, Ogunyemi E, Bello I, Idowu T, Subair H (2007). Toxicity studies on an unripe Carica papaya aqueous extract: biochemical and haematological effects in wistar albino rats. Journal of Medicinal Plants Research 1(1):001-004.


OECD (2001). Guidelines 420: Acute oral toxicity-fixed dose procedure. 



Ologhobo A, Adejumo I, Akangbe E (2014). Comparison effect of Moringa oleifera leaf meal and oxytetracycline on haematology and serum biochemical profile of broiler finishers. International Blood Research Reviews 2(1):29-36.


Osman HM, Shayoub ME, Babiker EM (2012). The effect of Moringa oleifera leaves on blood parameters and body weights of albino rats and rabbits. Jordan Journal of Biological Sciences 5(3):47-150.


Pramyothin P, Samosorn P, Poungshompoo S, Chaichantipyuth C (2006). The protective effects of Phyllanthus emblica Linn. extract on ethanol induced rat hepatic injury. Journal of Ethnopharmacology 107(3):361-364.


Sarwatt S, Kapange S, Kakengi A (2002). Substituting sunflower seed-cake with Moringa oleifera leaves as a supplemental goat feed in Tanzania. Agroforestry Systems 56(3):241-247.


Wannang NN, Jimam NS, Omale S, Dapar ML, Gyang SS, Aguiyi JC (2007). Effects of Cucumis metuliferus (Cucurbitaceae) fruits on enzymes and haematological parameters in albino rats. African Journal of Biotechnology 6(22).